# CFR AI - Title 21 — Clinical Research Assistant > AI assistant for navigating Title 21 of the Code of Federal Regulations. (iPhone/iPad app by Ryan Smerdon.) - Source: https://appshunter.io/ios/app/cfr-ai-title-21/id6478321436 (this page in markdown: same URL + `.md`) - Developer: [Ryan Smerdon](https://appshunter.io/developer/1732547078) - Category: Medical, Reference - Price: Free with in-app purchases - Rating: 5.00/5 from 1 App Store ratings - Age rating: 4+ - Requires: iOS 26.0 · 13 MB - Languages: American English - Released: 2024-04-22 - Data updated: 2026-08-22 - Monetization: subscription - User reviews in markdown: https://appshunter.io/ios/app/cfr-ai-title-21/id6478321436/reviews.md ## What is CFR AI? CFR AI - Title 21 is built for people who need a focused, modern workspace for Code of Federal Regulations Title 21 research and organization. Ask questions about Title 21 and get AI-assisted responses designed around current eCFR source material, citations, and a clear trust layer. The app also gives you a productivity hub for saved answers, deadlines, reminders, notes, and title-specific follow-up work. Key features: Live Title 21 CFR Chat Ask natural-language questions about Food and Drugs and receive structured AI responses with citation-oriented source context from current eCFR data. eCFR Trust Layer Responses are designed to highlight cited CFR sections, source context, and professional-use reminders so users understand what should be verified before relying on an answer. CFR Change Monitor Track Title 21 update context, recent amendment dates, saved sections, and CFR follow-up work. Citation Builder Build and save CFR references for research, case notes, follow-ups, and professional documentation. Compare Versions Compare CFR section text across available eCFR dates to better understand how regulations have changed over time. Food and Drugs Organizer Track CFR-related questions, review steps, target dates, statuses, and follow-up items for food and drugs work. Advanced Calendar Use an iOS-style calendar workspace with month, week, day, and agenda views for review blocks, appointments, deadlines, and saved chat answers. Reminders Create organized reminder lists with due dates, notes, priorities, tags, flagged items, scheduled items, and CFR follow-ups. Notes Save research notes, AI answers, citations, checklists, tags, folders, and longer CFR notes without losing important context. AI Action Buttons Save useful chatbot responses into calendar items, reminders, notes, and organizer workflows so research can turn into action. Important notice: CFR AI - Title 21 is an independent productivity and research tool. It is not affiliated with, endorsed by, or sponsored by the U.S. government, eCFR, or the Office of the Federal Register. The eCFR is continuously updated but is not the official legal edition of the CFR. AI responses should be reviewed against cited source material and should not be treated as legal, medical, benefits, or professional advice. Subscription required: Access to app features requires an active subscription. Subscriptions are managed through your Apple account and can be canceled in App Store account settings. Terms of Use (EULA): https://www.apple.com/legal/internet-services/itunes/dev/stdeula/ ## Key features - AI-powered Title 21 CFR inquiries - Instant, accurate regulatory answers - Interactive chatbot - Example questions for guidance - Calendar and reminder functionality - User-friendly interface ## Pricing and in-app purchases Base price: Free. **Subscriptions** | Subscription | Price | Period | | --- | --- | --- | | Weekly | $0.99 | per 7 days | | Monthly | $3.99 | per month | | Yearly | $45.99 | per year | | Bi-Annual | $23.99 | per 6 months | ## Frequently asked questions about CFR AI ### What is CFR AI? CFR AI is a subscription-based application designed to help professionals navigate Title 21 of the Code of Federal Regulations. It uses advanced AI to provide instant, accurate answers to questions related to drug development, clinical trials, and FDA regulations. ### Does CFR AI have ads? No, CFR AI does not contain advertisements. The application operates on a subscription model, offering full access to its features without interruptions from ads. ### What are the subscription options for CFR AI? CFR AI offers several subscription plans: a weekly plan for $0.99, a monthly plan for $3.99, a bi-annual plan for $23.99, and an annual plan for $45.99. All plans include a 3-day free trial. ### What devices is CFR AI available on? CFR AI is compatible with Mac, iPhone, iPad, and iPod devices, allowing users to access regulatory information across multiple Apple platforms. ### How often is CFR AI updated? The latest version of CFR AI is 4.1.1, and it was last updated on February 4, 2026. This indicates a commitment to regular updates for improved functionality and accuracy. ### What is the age rating for CFR AI? CFR AI has an age rating of 4+, making it suitable for a wide range of users. This rating suggests that the content is appropriate for general audiences. ### What AI technology powers CFR AI? CFR AI is powered by GPT-4o, one of the most advanced AI models available. This ensures that users receive sophisticated and up-to-date information regarding Title 21 CFR. ### Can I cancel my CFR AI subscription? Yes, users can cancel their CFR AI subscription. Details on cancellation policies are typically found within the app's subscription management section or the provided terms of use. ## Version history (last 5 releases) ### 5.1 — 2026-08-20 Major redesign with a modern red, white, and blue interface, live eCFR-focused Title 21 chat, StoreKit subscription paywall, citation builder, version comparison, CFR change monitoring, Food and Drugs Organizer, advanced calendar, reminders, notes, and improved save actions for complete AI responses. ### 4.1.1 — 2026-02-04 New Ui Now pulls live from eCFR ### 3.5 — 2024-12-29 Bug Fix ### 3.0 — 2024-09-11 Complete overhaul. Switch app over from SwiftUI language to Flutter language. Added : Calendar, Notes and Reminder in app function. ### 2.8.1 — 2024-07-30 Fixed version issue and set minimum OS to 17.0 ## Apps similar to CFR AI | App | Rating | Price | Category | | --- | --- | --- | --- | | [DM Nexus](https://appshunter.io/ios/app/dm-nexus/id6469770195) | 5.0 (1) | Free | Medical | | [Sofia Kompanion](https://appshunter.io/ios/app/sofia-kompanion/id6502032505) | 5.0 (3) | Free | Medical | | [Research Hive](https://appshunter.io/ios/app/research-hive/id1040112330) | 4.5 (8) | Free | Medical | | [Home Healthcare](https://appshunter.io/ios/app/home-healthcare/id1412149500) | 5.0 (2) | Free | Medical | | [Dermapix Mobile App](https://appshunter.io/ios/app/dermapix-mobile-app/id1484000268) | 5.0 (1) | Free | Medical | | [PatienTrials](https://appshunter.io/ios/app/patientrials/id1386748565) | 5.0 (1) | Free | Medical | ## More apps by Ryan Smerdon - [CFR AI - Title 40](https://appshunter.io/ios/app/cfr-ai-title-40/id6499383417) - [CFR AI - Title 49](https://appshunter.io/ios/app/cfr-ai-title-49/id6502741519) - [CFR AI - Title 29](https://appshunter.io/ios/app/cfr-ai-title-29/id6502909696) - [CFR AI - Title 12](https://appshunter.io/ios/app/cfr-ai-title-12/id6503028452) - [CFR AI - Title 26](https://appshunter.io/ios/app/cfr-ai-title-26/id6503179367) All apps by Ryan Smerdon: https://appshunter.io/developer/1732547078 --- *Data collected daily from the US App Store and indexed by [AppsHunter](https://appshunter.io/). User reviews are verbatim App Store reviews. Ratings, prices and chart positions refresh continuously; this snapshot is from 2026-08-22.*