# Heparin Heuristics Lite — Heparin dose and reversal

> Heparin dose and reversal (iPhone/iPad app by Philip Cumpston.)

- Source: https://appshunter.io/ios/app/heparin-heuristics-lite/id1499772855 (this page in markdown: same URL + `.md`)
- Developer: [Philip Cumpston](https://appshunter.io/developer/1170883918)
- Category: Medical, Productivity
- Price: $4.99 (on sale, was $5.99)
- Age rating: 17+
- Requires: iOS 15.0 · 11 MB
- Languages: American English, Dutch, French (France), German (Germany), Greek, Italian, Japanese, Chinese (Simplified, China), European Spanish
- Released: 2021-07-16
- Data updated: 2026-08-22
- User reviews in markdown: https://appshunter.io/ios/app/heparin-heuristics-lite/id1499772855/reviews.md

## What is Heparin Heuristics Lite?

Heparin Heuristics Lite
© 2017-  JHLConsultants
E-mail: pcumpston@JHLConsultants.com
This application is  based on the experience gained when providing anaesthetic care to over 1,000 patients undergoing catheter ablation for atrial fibrillation, and resulted from an approved clinical trial. The result of tis trial has been published in the Journal of AtrialFibrillation and Electrophysiology (Cumpston, P., & Phillips, K. P. (2024). A Novel Method for Calculating Heparin Dosing to Rapidly Achieve Target Anticoagulation for Cardiac Procedures. Journal of Atrial Fibrillation, 17(2).)
Disclaimer: This application must only be used by health professionals in the course of providing care to patients undergoing procedures where anticoagulation is required by the use of intravenous heparin, and where it is desired to reverse the anticoagulation with protamine. The decision to use this advice must be made by the supervising doctor, and cannot be used to replace clinical judgement.

This application is  based on the experience gained when providing anaesthetic care to over 1,000 patients undergoing catheter ablation for atrial fibrillation. It was developed during a clinical trial entitled "A Heuristic Approach to determine the optimal method of Heparin Dosing and Reversal in all Patients Undergoing Anaesthesia for Catheter Ablation for Atrial Fibrillation (CA-AF)", ANZCTR  Trial Id: ACTRN12618001489280 (https://www.anzctr.org.au) and approved by the Ramsay Human Ethics Committee: Clinical trial number 18/38 9th October 2019.

It can be used to estimate the initial bolus of heparin needed to achieve a desired ACT, given height, weight, sex, ACT before heparin and desired ACT.
The ACT must then be measured ten minutes after the inital heparin bolus and the result entered into the application in order to calculate the patient's individual ACT:heparin dose-response relationship. 

This timing is essential for accuracy of subsequent calculations and is critically important.

The application learns  as each new patient is added. After the first ten patients, accuracy for the intial heprin dose to achieve the desired ACT moves toward the 86% mark. There will, of course, be outliers.  The application allows for dose adjustments based on the measured ACT. Estimates of the protamine dose needed to reverse heparin in the context of catheter ablation cases has been shown to be 97% accurate.

This software is NOT intended by its manufacturer to: 
(a)     be used for the sole purpose of providing alerts to health professionals in relation to patient care; and
(b)    
        (i)	replace the clinical judgement of a health professional; or
       (ii)	diagnose, screen for, prevent, alleviate, treat, or make a decision about the treatment of, a disease, condition, ailment or defect

As each patient has details added, the application moves toward the average for the initial heparin dose calculations, but always uses the individual patient response to heparin to estimate the appropriate change in heparin bolus to achieve the desired ACT.

While this application helps guide the administration, maintenance and reversal of heparin, it is important to note that a normal ACT does not necessarily mean that there is no residual heparin, and does not mean that there is not an excess of protamine after reversal of heparin.

It is up to the individual practitioner to use their best judgment when using this application. It is not intended to replace clinical judgement by experience operators. For example, a protamine: heparin ratio of 0.8 to 1 may be considered optimal by some practitioners, but others may prefer the traditional 1:1 ratio.

The heparin image is taken from Public Domain, https://commons.wikimedia.org/w/index.php?curid=1034324 

Information and links to citations forming the basis for the theoretical development of this app can be found at: https://HeparinHeuristics.com


## Version history (last 5 releases)

### 8.1 — 2026-07-15

Completely rewritten to use trimmed median estimation of the heparin:ACT dose-response relationship for the first heparin dose estimation. The estimated blood volume formula has been modified to remove proportional bias.

References added for published literature in peer-reviewed medical journals showing that this app improves patient safety when used to help guide heparin administration.

Managing heparin anticoagulation in the operating theatre demands speed, accuracy, and individual patient awareness. Heparin Heuristics puts a pharmacodynamic dosing engine in your pocket.
What it does:
• Estimates the initial heparin bolus dose to achieve a target ACT range
• Adjusts recommendations based on observed individual patient response
• Calculates protamine reversal dose at procedure end
• Supports both cardiac surgery and interventional catheterisation workflows
Who it's for:
Cardiac anaesthetists, perfusionists, and interventional cardiologists who need a fast, structured alternative to weight-based approximations.

When a patient's height, weight, sex, pre-heparin ACT, and target ACT are entered, the app gives you an estimate of the starting dose that actually gets you within a desired range first time.  This isn't a calculator. It's a clinical model built around how heparin actually behaves. During the course of a procedure, recommendations are made for infusion rates and/or additional heparin doses to maintain the desired ACT (based on the individual patient's response to heparin). When reversal of heparin is desired, an estimate of the protamine dose needed is presented for consideration.
Heparin Heuristics is a decision-support tool. All clinical decisions remain the responsibility of the treating clinician.

### iOS App Version 7.6 — 2025-07-22

Support for modification of infusion rates according to the difference between the desired and achieved ACT. Improved algorithm for helping to determine the suggested dose of heparin to achieve a desired ACT.  The app now uses the 20% trimmed median value for prediction of the initial heparin dose, and this is adjusted after each patient is added to the data.

### 7.4 — 2025-02-07

Available in multiple European languages, Japanese and simplified Chinese. A number of bug fixes that improve functionality.
iPad version greatly improved.

### 6.20.276 — 2024-07-22

Now available in French, German, Dutch, Spanish, Italian, Greek, Japanese and simplified Chinese. I have done my best to translate from English using DeepL and Google translate. Please contact the author if any errors appear.

### 5.4 — 2022-01-07

Minor bug fixes
Correction de bugs mineurs
Kleinere Fehlerbehebungen

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All apps by Philip Cumpston: https://appshunter.io/developer/1170883918

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*Data collected daily from the US App Store and indexed by [AppsHunter](https://appshunter.io/). User reviews are verbatim App Store reviews. Ratings, prices and chart positions refresh continuously; this snapshot is from 2026-08-22.*
