# iTIVA Anesthesia Plus — TCI Simulator

> Pharmacokinetic/pharmacodynamic simulation app for drug concentration estimation and infusion optimization. (iPhone/iPad app by ANESTESIARTE CALI SAS.)

- Source: https://appshunter.io/ios/app/itiva-anesthesia-plus/id1442975682 (this page in markdown: same URL + `.md`)
- Developer: [ANESTESIARTE CALI SAS](https://appshunter.io/developer/782878902)
- Category: Medical, Education
- Price: Free with in-app purchases
- Rating: 4.80/5 from 330 App Store ratings · 11 written reviews indexed
- Age rating: 17+
- Requires: iOS 11.0 · 125 MB
- Languages: American English, French (France), European Spanish
- Released: 2018-12-01
- Data updated: 2026-08-27
- Monetization: subscription
- User reviews in markdown: https://appshunter.io/ios/app/itiva-anesthesia-plus/id1442975682/reviews.md

## What is iTIVA Anesthesia Plus?

Introducing iTIVA: Your Ultimate Pharmacokinetic / Pharmacodynamic Simulation App

Are you a medical professional looking to enhance precision and efficiency in drug administration while expanding your knowledge in pharmacokinetics? Look no further than iTIVA, the leading pharmacokinetic/pharmacodynamic simulation application designed to revolutionize the way you estimate drug concentrations in plasma and optimize infusion schemes!

Key Features:

• Accurate Drug Concentration Estimation:
Harness the power of cutting-edge mathematical models to estimate drug concentrations in plasma. iTIVA offers an extensive library of 28 drugs and 70 pharmacokinetic models, empowering you to control anesthesia IV drugs like an expert.

• Target Controlled Infusion (TCI) Simulation:
Take control of TCI pumps like never before! iTIVA simulates TCI pump behavior, allowing you to calculate infusion schemes to attain and maintain desired target concentrations in plasma or effect site. It's like having a reliable assistant right at your fingertips.

• Comprehensive Drug Library:
From Remifentanil, Propofol to Heparin and beyond, iTIVA boasts an impressive range of 28 drugs to cater to your unique needs.

(Remifentanil, Fentanyl, Sufentanil, Alfentanil, Hydromorphone, Morphine, Ketamine, Procaine, Lidocaine, Propofol, Etomidate, Dexmedetomidine, Midazolam, Remimazolam, Thiopental, Atracurium, Cisatracurium, Rocuronium, Vecuronium, Sugammadex, Tranexamic, Magnesium sulfate, Diazepam, Heparin and Protamine)

• Explore Drug Interactions:
With 70 pharmacokinetic models and 10 pharmacodynamic models at your disposal, iTIVA facilitates in-depth exploration of drug interactions.

• MAC Age Calculation:
Quickly determine end-tidal (Et) concentration for Isoflurane, Sevoflurane, and Desflurane using the Mapleson equation. No more guesswork – iTIVA streamlines the process for you.

• Intraoperative Milestones & Case Sharing:
Record crucial intraoperative milestones and effortlessly share cases with colleagues using QR codes. Collaboration has never been this seamless!

• Save and Run Multiple Simulations:
Save your simulation cases for future review or run multiple simulations simultaneously. iTIVA adapts to your workflow and maximizes efficiency.

• Excel Data Export:
All recorded information can be conveniently exported as an Excel file. Stay organized and analyze your data with ease.

iTIVA's yearly subscription is available for US$9,99/year. 
• The subscription will be charged to iTunes Account at confirmation of purchase
• Subscription automatically renews unless auto-renew is turned off at least 24-hours before the end of the current period
• The account will be charged for renewal within 24-hours before the end of the current period, and identify the cost of the renewal
• Subscriptions may be managed by the user and auto-renewal may be turned off by going to the user's Account Settings after purchase
• Any unused portion of a free trial period, if offered, will be forfeited when the user purchases a subscription to that publication, where applicable

More details can be found here 
iTIVA Privacy Policy: https://itiva.co/privacy.html
Terms and Conditions: http://itiva.co/terms.html

## Key features

- Accurate drug concentration estimation
- Target Controlled Infusion (TCI) simulation
- Comprehensive drug library (28 drugs)
- Explore drug interactions (70 PK, 10 PD models)
- MAC Age Calculation
- Intraoperative milestones & case sharing
- Save and run multiple simulations
- Excel data export

## Pricing and in-app purchases

Base price: Free.

**Subscriptions**

| Subscription | Price | Period |
| --- | --- | --- |
| iTIVA yearly | $9.99 | per year |
| iTIVA yearly 2021 | $9.99 | per year |


## Recent user reviews (10 of 11)

All indexed reviews: https://appshunter.io/ios/app/itiva-anesthesia-plus/id1442975682/reviews.md

### 5/5 — Excelente

*2026-04-10*

Um ótimo app.

### 4/5 — pharmaco kinetic graph

*2026-02-26*

I am using v.2.7.2. Even after administering ketamine, the drug pharmacokinetic graph does not display.

**Developer response:** Hi, please contact me to david@itiva.co, to assist you

### 1/5 — Non-intuitive frustrating app

*2024-11-25, version 2.6.7*

I have no idea how good or bad this thing is.  I don’t want to watch hours of monotone tutorials to figure it out. I tried watching a YouTube video.  My god. Horrible, Frustrating, Slow and Remi as an example. Really? I just can’t get it to start. It shouldn’t be this difficult. Input bolus and infusion time. Got that done. Now just tell me what is the current concentration and guide for target concentration and I’ll obey or not based on the EEG. Instead it’s stuck nowhere. Meaning I’m not finding the correct button to click to start the app.

### 5/5 — Too difficult to use!

*2023-08-16*

This app is too difficult to
Use. We wanted a real time manual Propofol infusion of 40 mcg/kg/min, a simple pump infusion, not TCI, but just a simple real time infusion, with an ability to see a decrease in BIS, as you would see in a patient on a manual
Propofol infusion of 40 mcg/kg/min on the pump in real rime. This is something you might see in ICU, for a vent patient requiring mild sedation. We couldn’t even simulate this.

**Developer response:** We have addressed concerns regarding user questions and doubts. iTIVA offers the capability to simulate any infusion scheme for the most commonly used IV anesthetics in various clinical settings, including the OR, ICU, and emergency department. Additionally, you have the flexibility to adjust the unit of measurement from milligrams to micrograms, and from hours to minutes, providing you with a more personalized and adaptable experience.

We greatly appreciate your feedback and thank you for bringing this to our attention. Your satisfaction is of utmost importance to us, and we are committed to continually enhancing your experience with iTIVA.

-----

Hello,
I apologize for the inconvenience you experienced while using our app. Your feedback is valuable to us, and I'm sorry we couldn't provide the specific real-time manual Propofol infusion experience you were looking for.

To assist you better, I'd like to offer a solution. Please reach out to us at david@itiva.co, and I'll be more than happy to provide you with instructional videos that explain how to simulate the exact Propofol infusion scenario you mentioned. Your satisfaction is important to us, and we're committed to ensuring that you have a smoother experience with iTIVA Plus.

Thank you for bringing this to our attention, and I look forward to helping you achieve the simulation you're seeking.

### 5/5 — Extremely useful and versatile

*2022-10-31, version 2.5*

I have used this app for 18 months now on hundreds of cases. Nothing compares really Enables use of TCI infusions schemes even if you don’t have the pumps, with great precision. Even better than most actual pumps because: -All major pk/pd models are available, even the new general open TCI models (Eleveld for profofol and remifentanil, dexmedetomidine,…) for lots of molecules. Commercial pumps are much more limited. -Flexibility : you can combine manual boluses/perfusions and switch to TCI (or the other way around) -You can simulate 2 models for the same drug side by side to compare the models. Or just simulate different drugs on different patient types (pediatrics, obese, elderly) to refine your understanding of pharmacokinetics. -Great tool for resident teaching. Philippe Picard

### 3/5 — Please support iPad 4!

*2022-02-18*

Hello, I’m trying to use this app on my iPad 4th generation (iOS 10.3.3) and it doesn’t allow the installation, saying it isn’t compatible with the device. Please help!

**Developer response:** Hi, finally I tried to support 10.3.3 version, but it can't be supported any more because apple policies. Sorry

### 5/5 — Nice simulator to use in the OR

*2021-02-16*

This app is great to simulate and guide your IV drugs in the OR

**Developer response:** Thanks for your review

### 5/5 — Anderson Assumpcao

*2020-07-05*

👏🏻👏🏻👏🏻

**Developer response:** Thank you for you review!!

### 3/5 — Handy, bu a bit clunky

*2020-05-29*

A restart/back to setup option is needed.

**Developer response:** To restart or back to the main screen, swipe to the right to open the menu, the press back!
Watch this tutorial
https://www.youtube.com/watch?v=cklrk2JYIY0

### 4/5 — A really helpful app

*2020-03-09, version 1.7*

This is a great app. I use it in my practice.

I appreciate that the app developer’s native language is not English, but I feel this app really needs a YouTube tutorial that is not in Spanish (the only current option). I think the program is capable of a lot, but currently it is necessary to kind of guess your way through the interface. The included “tutorial” is of some use, but a proper video walk-through of a commonly used simulation (like remi/propofol for, say, a lap chole) would be very helpful.

There has a been a ton of effort placed into this program and I have subscribed because I think this is a great clinical and teaching tool. I hope the developer keeps the updates coming!

## Frequently asked questions about iTIVA Anesthesia Plus

### What does iTIVA Anesthesia Plus do?

iTIVA Anesthesia Plus is a pharmacokinetic/pharmacodynamic simulation application designed to help medical professionals estimate drug concentrations in plasma and optimize infusion schemes. It simulates Target Controlled Infusion (TCI) pump behavior and allows for the calculation of infusion rates to achieve target drug levels.

### What are the key features of this app?

Key features include accurate drug concentration estimation using advanced mathematical models, simulation of TCI pumps, a comprehensive library of 28 drugs with 70 pharmacokinetic and 10 pharmacodynamic models, MAC Age Calculation for inhaled anesthetics, the ability to record and share intraoperative milestones, save multiple simulations, and export data to Excel.

### How much does iTIVA Anesthesia Plus cost?

The app offers a yearly subscription for US$9.99/year. This subscription automatically renews unless auto-renewal is turned off at least 24 hours before the end of the current period. Users can manage their subscriptions in their Account Settings.

### Who is this app intended for?

This app is intended for medical professionals, such as anesthesiologists, who need to enhance precision and efficiency in drug administration and expand their knowledge of pharmacokinetics and pharmacodynamics. It is particularly useful for those involved in anesthesia and critical care.

### Can I use this app to simulate different drug scenarios?

Yes, the app allows you to save and run multiple simulations simultaneously. With a comprehensive drug library and numerous pharmacokinetic and pharmacodynamic models, you can explore various drug interactions and infusion strategies to achieve desired target concentrations.

## Version history (last 5 releases)

### 2.7.4 — 2026-04-01

This update from Apple will improve the functionality of this app. No new features are included.

- Subscription bug fix.

### 2.7.2 — 2026-02-24

- Minor bugs fixed

### 2.7.1 — 2025-09-28

- Minor bugs
- Corrected Ketamine kamp model name

### 2.7 — 2025-02-26

-Added new Ketamine model: Domino-Navarrete
- Fixed a bug that prevented to show estimated ACT

### 2.6.7 — 2024-05-28

- Fixed a bug that prevented sharing cases through Airdrop / Whatsapp
(Press More button, then Share)

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## More apps by ANESTESIARTE CALI SAS

- [iTIVA Anesthesia](https://appshunter.io/ios/app/itiva-anesthesia/id635652167)

All apps by ANESTESIARTE CALI SAS: https://appshunter.io/developer/782878902

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*Data collected daily from the US App Store and indexed by [AppsHunter](https://appshunter.io/). User reviews are verbatim App Store reviews. Ratings, prices and chart positions refresh continuously; this snapshot is from 2026-08-27.*