# TIVAinSight — TIVA PK/PD teaching simulator

> TIVA PK/PD teaching simulator (iPhone/iPad app by Michiyoshi Sanuki.)

- Source: https://appshunter.io/ios/app/tivainsight/id6818753452 (this page in markdown: same URL + `.md`)
- Developer: [Michiyoshi Sanuki](https://appshunter.io/developer/6797550055)
- Category: Medical, Education
- Price: Free
- Age rating: 17+
- Requires: iOS 17.0 · 2 MB
- Languages: Japanese
- Released: 2026-10-08
- Data updated: 2026-10-11
- User reviews in markdown: https://appshunter.io/ios/app/tivainsight/id6818753452/reviews.md

## What is TIVAinSight?

TIVAinSight is a PK/PD simulator that calculates and plots the plasma (Cp) and effect-site (Ce) concentrations of intravenous anesthetics and opioids given by infusion or bolus, using a three-compartment model with an effect site. It is software for the education and research of anesthesiologists, residents and other clinicians. It is not a medical device and must not be used for dosing decisions or dosing plans in actual patients.

Features
- Four drugs (propofol, remimazolam, remifentanil, fentanyl) and 17 PK/PD models (Marsh, Schnider, Eleveld, Kataria, Short, Paedfusor, Minto, Kim, Rigby-Jones, Shafer, Scott, Masui, Schüttler and more)
- Two drugs at once, each in Manual (rate), TCI (plasma target) or ETCI (effect-site target) mode
- Boluses, per-kg bolus chips and quick chips for common targets and rates
- Fast-forward from x1 to x300 (the calculation always uses a 1-second step with the classical fourth-order Runge–Kutta method)
- Chart with a callout that always shows the current Cp, Ce, infusion rate and total dose (can be hidden; shows the values at the cursor when you point at a time), two Y axes, drag to pan, pinch or drag the time axis to zoom time, and scale each Y axis
- Settings in tabs (left panel on the wide screen of a Mac or iPad, bottom panel on iPhone), usable without scrolling on typical screen sizes; on iPhone the chart keeps its size when you switch tabs
- CSDT / CSHT: predicted time for Ce to fall by a chosen percentage or to a custom target after stopping the infusion
- Presentation mode (Mac and iPad): enlarged chart, readouts, chips and CSDT for projecting in lectures and talks (full screen on Mac)
- mL/h dose unit: set the syringe concentration to enter and show rates in mL/h and boluses in mL
- Patient presets (adult, elderly, child, infant) and body-size indices (BMI, LBM, FFM, ...)
- Verification screen: runs, on this device, the same Level-1 verification as the manuscript (43 runs, 720,092 values compared with the exact matrix-exponential solution) and 24 published reference checks
- References (DOI, PMID), populations and parameters for every model
- CSV export; Japanese and English interface

The app follows the same calculation procedure as the web version of TIVAinSight (https://msanuki.com/TIVAinSight/) and gives the same values for the same inputs.

Notes
- The Cp / Ce values are model-based estimates and are not guaranteed to match measured values.
- Do not use it, including the TCI / ETCI displays, paediatric models and mL/h conversions, for dosing decisions or dosing plans in actual patients. Real TCI pumps use algorithms validated by their manufacturers.
- All calculations stay on your device; nothing is sent anywhere. There is no account, advertising or analytics.

Author: Michiyoshi Sanuki, MD, PhD (anesthesiologist)
Copyright (c) Michiyoshi Sanuki, 2026


## Version history (last 1 release)

### 1.0 — 2026-10-08

No release notes.

## More apps by Michiyoshi Sanuki

- [麻酔と救急のために](https://appshunter.io/ios/app/id6797550053)
- [EEG DSA Viewer](https://appshunter.io/ios/app/eeg-dsa-viewer/id6814561806)

All apps by Michiyoshi Sanuki: https://appshunter.io/developer/6797550055

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*Data collected daily from the US App Store and indexed by [AppsHunter](https://appshunter.io/). User reviews are verbatim App Store reviews. Ratings, prices and chart positions refresh continuously; this snapshot is from 2026-10-11.*