# Protein Guide vs Codon One

The clearest difference is in-app purchases: Protein Guide at none against Codon One's 7. Protein Guide also leads on rating (4.8 vs 4.5) and iOS requirement (11.0 vs 15.6). Codon One's advantage is update cadence (every 3 weeks vs every 9 months) and review sentiment (76% vs 50%). On price, ratings volume, ads and device support there is nothing between them.

Both are free to download. Codon One sells 7 one-off in-app purchases. Protein Guide asks for nothing beyond the download.

Protein Guide holds the better App Store score, 4.8 against 4.5. Both are backed by a comparable volume of ratings — 45 and 24 respectively. Written reviews complicate that: 50% of Protein Guide's written reviews are positive against 76% of Codon One's, so the app with the better star average is not the one people write more warmly about.

Protein Guide ships an update every 9 months, Codon One every 3 weeks. Both last shipped on October 24, 2026.

## The numbers

| Metric | Protein Guide | Codon One |
| --- | --- | --- |
| Price | Free | Free |
| Rating | **[4.8 (45 ratings)](https://appshunter.io/ios/app/protein-guide/id1375157917/reviews)** | [4.5 (24 ratings)](https://appshunter.io/ios/app/codon-one-biology-study/id1517313390/reviews) |
| Number of ratings | **45** | 24 |
| Positive reviews | 50.0% of reviews | **76.5% of reviews** |
| In-app purchases | **No** | Yes |
| Ads | No | No |
| Update frequency | Every 9 months | **Every 3 weeks** |
| Monetization | **Free** | Free with in-app purchases |
| Size | 224 MB | 277 MB |
| Requires iOS | **11.0** | 15.6 |
| Devices | iPhone, iPad, iPod | iPhone, iPad, iPod |
| Age rating | 4+ | 4+ |
| Developer | [Axton Pitt](https://appshunter.io/developer/957165645) | [Daniel Gebert](https://appshunter.io/developer/1517313389) |

## What reviewers say

### Protein Guide

[App page](https://appshunter.io/ios/app/protein-guide/id1375157917)

Explore the intricate stages of protein structure with detailed diagrams, explanations, and animations. This app serves as a valuable reference for both beginners and experienced individuals, offering insights into unique properties and biological functions.

**Highlights:** Detailed diagrams of protein structure, Explanations of protein stages, Animations of protein structures, Information on unique properties and functions, Example proteins demonstrating structural aspects, ClassKit integration for teachers

**Features:** macOS Compatibility

**In-app purchases:** none


### Codon One

[App page](https://appshunter.io/ios/app/codon-one-biology-study/id1517313390)

Master molecular biology, genetics, evolution, and life chemistry through interactive modules and quizzes. Explore essential concepts with clear diagrams and concise explanations. Includes helpful tools for sequence analysis and genetic code reference.

**Highlights:** Interactive learning modules, Quick quizzes for comprehension, Clear diagrams and plain language, Molecule reference guide, Sequence analysis tools, Genetic code exploration

**Features:** Family Sharing, Vision Pro support

**In-app purchases (7)**

| Purchase | Price | Billing |
| --- | --- | --- |
| Module 1: Chemistry of Life | Free | one-time |
| Module 2: Genetics | $2.99 | one-time |
| Module 3: Evolution | $2.99 | one-time |
| Module 4: Science History | $2.99 | one-time |
| Module 5: Cell Biology | $2.99 | one-time |
| Module 6: Development | $2.99 | one-time |
| Unlock All | $8.99 | one-time |


## Frequently asked questions

### Is Protein Guide free?

Protein Guide is free to download, with no in-app purchases.

### Is Codon One free?

Codon One is free to download, with in-app purchases available.

### Which has better reviews, Protein Guide or Codon One?

Protein Guide is rated higher. Protein Guide averages 4.8 out of 5 from 45 ratings, while Codon One averages 4.5 from 24 ratings.

### Do Protein Guide or Codon One have ads?

Neither Protein Guide nor Codon One shows ads.

### Which is updated more often, Protein Guide or Codon One?

Protein Guide ships an update every 9 months, and Codon One every 3 weeks. Most recently, Protein Guide was updated on October 24, 2026 and Codon One on October 24, 2026.

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*Compared by [AppsHunter](https://appshunter.io/) from daily US App Store data. Review summaries are generated from verbatim App Store reviews.*