# iTIVA Anesthesia Plus vs Regional Anesthesia Reference

The clearest difference is in-app purchases: Regional Anesthesia Reference at none against iTIVA Anesthesia Plus's 2. Regional Anesthesia Reference also leads on review sentiment (89% vs 73%) and rating (5.0 vs 4.8). iTIVA Anesthesia Plus's advantage is update cadence (every 2 months vs every 5 months) and ratings volume (330 vs 32). On price, ads and device support there is nothing between them.

Both are free to download. iTIVA Anesthesia Plus sells 2 in-app purchases, starting at $9.99 per year. Regional Anesthesia Reference asks for nothing beyond the download.

Regional Anesthesia Reference holds the better App Store score, 5.0 against 4.8. That said, the two scores are not equally well evidenced: iTIVA Anesthesia Plus has 330 ratings behind it against 32, so its average is the more settled of the two. Written reviews point the same way: 73% of iTIVA Anesthesia Plus's written reviews are positive against 89% of Regional Anesthesia Reference's.

iTIVA Anesthesia Plus ships an update every 2 months, Regional Anesthesia Reference every 5 months. The most recent releases landed on October 16, 2026 and October 11, 2026 respectively.

## The numbers

| Metric | iTIVA Anesthesia Plus | Regional Anesthesia Reference |
| --- | --- | --- |
| Price | Free | Free |
| Rating | [4.8 (330 ratings)](https://appshunter.io/ios/app/itiva-anesthesia-plus/id1442975682/reviews) | **[5.0 (32 ratings)](https://appshunter.io/ios/app/regional-anesthesia-reference/id1445967461/reviews)** |
| Number of ratings | **330** | 32 |
| Positive reviews | 72.7% of reviews | **88.9% of reviews** |
| In-app purchases | Yes | **No** |
| Ads | No | No |
| Update frequency | **Every 2 months** | Every 5 months |
| Monetization | Subscription | **Free** |
| Size | 125 MB | 89 MB |
| Requires iOS | 11.0 | **8.0** |
| Devices | iPhone, iPad, iPod | iPhone, iPad, iPod |
| Age rating | 17+ | 17+ |
| Developer | [ANESTESIARTE CALI SAS](https://appshunter.io/developer/782878902) | [University Of Washington](https://appshunter.io/developer/328228464) |

## What reviewers say

### iTIVA Anesthesia Plus

[App page](https://appshunter.io/ios/app/itiva-anesthesia-plus/id1442975682)

This app simulates drug concentrations in plasma and optimizes infusion schemes for medical professionals. It offers a comprehensive drug library, target-controlled infusion simulation, and MAC age calculation. Users can explore drug interactions, share cases, and export data.

**Highlights:** Accurate drug concentration estimation, Target Controlled Infusion (TCI) simulation, Comprehensive drug library (28 drugs), Explore drug interactions (70 PK, 10 PD models), MAC Age Calculation, Intraoperative milestones & case sharing, Save and run multiple simulations, Excel data export

**Features:** macOS Compatibility, Vision Pro support

**In-app purchases (2)**

| Purchase | Price | Billing |
| --- | --- | --- |
| iTIVA yearly | $9.99 | per year |
| iTIVA yearly 2021 | $9.99 | per year |


### Regional Anesthesia Reference

[App page](https://appshunter.io/ios/app/regional-anesthesia-reference/id1445967461)

This app offers a quick reference for regional nerve block placement using ultrasound. It includes detailed anatomy, patient positioning, and technique videos, along with a local anesthetic drug calculator.

**Highlights:** Ultrasound guidance for nerve blocks, Anatomy and positioning guides, Block placement technique videos, Local anesthetic drug calculator, List of current blocks

**Features:** macOS Compatibility

**In-app purchases:** none


## Frequently asked questions

### Is iTIVA Anesthesia Plus free?

iTIVA Anesthesia Plus is free to download, with in-app purchases available.

### Is Regional Anesthesia Reference free?

Regional Anesthesia Reference is free to download, with no in-app purchases.

### Which has better reviews, iTIVA Anesthesia Plus or Regional Anesthesia Reference?

Regional Anesthesia Reference is rated higher. iTIVA Anesthesia Plus averages 4.8 out of 5 from 330 ratings, while Regional Anesthesia Reference averages 5.0 from 32 ratings.

### Do iTIVA Anesthesia Plus or Regional Anesthesia Reference have ads?

Neither iTIVA Anesthesia Plus nor Regional Anesthesia Reference shows ads.

### Which is updated more often, iTIVA Anesthesia Plus or Regional Anesthesia Reference?

iTIVA Anesthesia Plus ships an update every 2 months, and Regional Anesthesia Reference every 5 months. Most recently, iTIVA Anesthesia Plus was updated on October 16, 2026 and Regional Anesthesia Reference on October 11, 2026.

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*Compared by [AppsHunter](https://appshunter.io/) from daily US App Store data. Review summaries are generated from verbatim App Store reviews.*