# Open CLS vs Guide Dose

The clearest difference is in-app purchases: Open CLS at none against Guide Dose's 2. Open CLS also leads on iOS requirement (13.0 vs 15.5). Guide Dose's advantage is update cadence (every 5 days vs every 24 months). On price, ads and device support there is nothing between them.

Both are free to download. Guide Dose sells 2 in-app purchases, starting at $9.99 per month. Open CLS asks for nothing beyond the download.

Open CLS ships an update every 24 months, Guide Dose every 5 days. Both last shipped on November 3, 2026.

## The numbers

| Metric | Open CLS | Guide Dose |
| --- | --- | --- |
| Price | Free | Free |
| Positive reviews | — | 85.7% of reviews |
| In-app purchases | **No** | Yes |
| Ads | No | No |
| Update frequency | Every 24 months | **Every 5 days** |
| Monetization | — | Subscription |
| Size | 17 MB | 144 MB |
| Requires iOS | **13.0** | 15.5 |
| Devices | iPhone, iPad, iPod | iPhone, iPad, iPod |
| Age rating | 12+ | 12+ |
| Developer | [Clinical Leadership Solutions LTD](https://appshunter.io/developer/1434082548) | [MedCalc](https://appshunter.io/developer/1699306069) |

## What reviewers say

### Open CLS

[App page](https://appshunter.io/ios/app/open-cls/id1479939378)

**In-app purchases:** none


### Guide Dose

[App page](https://appshunter.io/ios/app/guide-dose-for-physicians/id6453359266)

This app provides healthcare professionals and students with quick access to clinical information, drug doses, and decision-support tools. It features a structured experience for study, reference, and organizing medical data, including AI-powered informational support.

**Highlights:** Search by medication or indication, Patient profile for contextualized readings, Organized clinical references and labeling, Modules on physiology, medications, and CPR, Clinical AI for informational support, Protocols and consultation flows, Auxiliary clinical tools

**Features:** macOS Compatibility

**In-app purchases (2)**

| Purchase | Price | Billing |
| --- | --- | --- |
| Guide Dose Pro (monthly) | $9.99 | per month |
| Guide Dose Pro (annual) | $69.99 | per year |


## Frequently asked questions

### Is Open CLS free?

Open CLS is free to download, with no in-app purchases.

### Is Guide Dose free?

Guide Dose is free to download, with in-app purchases available.

### Do Open CLS or Guide Dose have ads?

Neither Open CLS nor Guide Dose shows ads.

### Which is updated more often, Open CLS or Guide Dose?

Open CLS ships an update every 24 months, and Guide Dose every 5 days. Most recently, Open CLS was updated on November 3, 2026 and Guide Dose on November 3, 2026.

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*Compared by [AppsHunter](https://appshunter.io/) from daily US App Store data. Review summaries are generated from verbatim App Store reviews.*