# CTCAE 6 Pro vs IOTOX Algorithm

The clearest difference is in-app purchases: IOTOX Algorithm at none against CTCAE 6 Pro's 2. CTCAE 6 Pro's advantage is ratings volume (10 vs 1) and device support (3 vs 1). On price, rating, update cadence and ads there is nothing between them.

Both are free to download. CTCAE 6 Pro sells 2 in-app purchases, starting at $1.99 per month. IOTOX Algorithm asks for nothing beyond the download.

On the App Store both sit at effectively the same score — 5.0 for CTCAE 6 Pro against 5.0 for IOTOX Algorithm. That said, the two scores are not equally well evidenced: CTCAE 6 Pro has 10 ratings behind it against 1, so its average is the more settled of the two.

CTCAE 6 Pro ships an update every 3 weeks, IOTOX Algorithm every 6 weeks. The most recent releases landed on October 30, 2026 and October 22, 2026 respectively.

## The numbers

| Metric | CTCAE 6 Pro | IOTOX Algorithm |
| --- | --- | --- |
| Price | Free | Free |
| Rating | [5.0 (10 ratings)](https://appshunter.io/ios/app/ctcae-6-pro/id1625560237/reviews) | [5.0 (1 ratings)](https://appshunter.io/ios/app/iotox-algorithm/id6744123485/reviews) |
| Number of ratings | **10** | 1 |
| In-app purchases | Yes | **No** |
| Ads | No | No |
| Update frequency | **Every 3 weeks** | Every 6 weeks |
| Monetization | Freemium | **Free** |
| Size | 87 MB | 7 MB |
| Requires iOS | **15.6** | 18.0 |
| Devices | **iPhone, iPad, iPod** | iPhone |
| Age rating | 17+ | 17+ |
| Developer | [Koichiro Watanabe](https://appshunter.io/developer/1077985400) | [MD Anderson Cancer Center](https://appshunter.io/developer/618340093) |

## What reviewers say

### CTCAE 6 Pro

[App page](https://appshunter.io/ios/app/ctcae-6-pro/id1625560237)

This app provides easy access to CTCAE 6.0 content, allowing users to bookmark adverse events, search for keywords, and organize notes. It offers features for version comparison, data export, and timeline management for premium subscribers.

**Highlights:** Quick CTCAE 6.0 content access, Unlimited bookmarking of adverse events, Keyword search with highlighting, Local data storage for privacy, Version comparison (5.0 vs 6.0), Smart notes and chronological organization, Spreadsheet to custom list app conversion

**Features:** macOS Compatibility, Vision Pro support

**In-app purchases (2)**

| Purchase | Price | Billing |
| --- | --- | --- |
| Premium Plan – Monthly | $1.99 | per month |
| Premium Plan – Annual | $9.99 | per year |


### IOTOX Algorithm

[App page](https://appshunter.io/ios/app/iotox-algorithm/id6744123485)

This app provides clinical management algorithms for evaluating, diagnosing, and treating toxicities associated with cancer immunotherapies. It guides physicians on best practices for managing side effects that can arise during cancer treatment.

**Highlights:** Clinical management algorithms, Evaluation of toxicities, Diagnosis of side effects, Treatment of immunotherapy toxicities, Best practices for patient care

**Features:** macOS Compatibility, Vision Pro support

**In-app purchases:** none


## Frequently asked questions

### Is CTCAE 6 Pro free?

CTCAE 6 Pro is free to download, with in-app purchases available.

### Is IOTOX Algorithm free?

IOTOX Algorithm is free to download, with no in-app purchases.

### Which has better reviews, CTCAE 6 Pro or IOTOX Algorithm?

CTCAE 6 Pro and IOTOX Algorithm are both rated 5.0 out of 5 on the App Store, from 10 and 1 ratings respectively.

### Do CTCAE 6 Pro or IOTOX Algorithm have ads?

Neither CTCAE 6 Pro nor IOTOX Algorithm shows ads.

### Which is updated more often, CTCAE 6 Pro or IOTOX Algorithm?

CTCAE 6 Pro ships an update every 3 weeks, and IOTOX Algorithm every 6 weeks. Most recently, CTCAE 6 Pro was updated on October 30, 2026 and IOTOX Algorithm on October 22, 2026.

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*Compared by [AppsHunter](https://appshunter.io/) from daily US App Store data. Review summaries are generated from verbatim App Store reviews.*