# CTCAE 5 Pro vs IOTOX Algorithm

The clearest difference is in-app purchases: IOTOX Algorithm at none against CTCAE 5 Pro's 2. CTCAE 5 Pro's advantage is device support (3 vs 1) and iOS requirement (15.5 vs 18.0). On price, update cadence and ads there is nothing between them.

Both are free to download. CTCAE 5 Pro sells 2 in-app purchases, starting at $1.99 per month. IOTOX Algorithm asks for nothing beyond the download.

CTCAE 5 Pro ships an update every 5 weeks, IOTOX Algorithm every 6 weeks. The most recent releases landed on September 22, 2026 and September 18, 2026 respectively.

## The numbers

| Metric | CTCAE 5 Pro | IOTOX Algorithm |
| --- | --- | --- |
| Price | Free | Free |
| Rating | **[4.8 (38 ratings)](https://appshunter.io/ios/app/ctcae-5-pro/id1625569535/reviews)** | — |
| Number of ratings | **38** | — |
| Positive reviews | 0.0% of reviews | — |
| In-app purchases | Yes | **No** |
| Ads | No | No |
| Update frequency | **Every 5 weeks** | Every 6 weeks |
| Monetization | Freemium | — |
| Size | 60 MB | 7 MB |
| Requires iOS | **15.5** | 18.0 |
| Devices | **iPhone, iPad, iPod** | iPhone |
| Age rating | 17+ | 17+ |
| Developer | [Koichiro Watanabe](https://appshunter.io/developer/1077985400) | [MD Anderson Cancer Center](https://appshunter.io/developer/618340093) |

## What reviewers say

### CTCAE 5 Pro

[App page](https://appshunter.io/ios/app/ctcae-5-pro/id1625569535)

This app helps review and take notes on CTCAE documents. It offers local data storage for privacy and premium features like version comparison and advanced note-taking with a subscription.

**Highlights:** Streamlined CTCAE Document Access, Local data storage for enhanced privacy, Version comparison tool, Advanced chronological note-taking with hashtags, Custom app creation from spreadsheets, Flexible backup and archiving (XLSX, CSV)

**Features:** macOS Compatibility, Family Sharing, Vision Pro support

**In-app purchases (2)**

| Purchase | Price | Billing |
| --- | --- | --- |
| Monthly subscription | $1.99 | per month |
| Annual subscription | $9.99 | per year |


### IOTOX Algorithm

[App page](https://appshunter.io/ios/app/iotox-algorithm/id6744123485)

**Features:** macOS Compatibility, Vision Pro support

**In-app purchases:** none


## Frequently asked questions

### Is CTCAE 5 Pro free?

CTCAE 5 Pro is free to download, with in-app purchases available.

### Is IOTOX Algorithm free?

IOTOX Algorithm is free to download, with no in-app purchases.

### Do CTCAE 5 Pro or IOTOX Algorithm have ads?

Neither CTCAE 5 Pro nor IOTOX Algorithm shows ads.

### Which is updated more often, CTCAE 5 Pro or IOTOX Algorithm?

CTCAE 5 Pro ships an update every 5 weeks, and IOTOX Algorithm every 6 weeks. Most recently, CTCAE 5 Pro was updated on September 22, 2026 and IOTOX Algorithm on September 18, 2026.

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*Compared by [AppsHunter](https://appshunter.io/) from daily US App Store data. Review summaries are generated from verbatim App Store reviews.*