# UpToDate vs Sanford Guide Antimicrobial

The clearest difference is review sentiment: Sanford Guide Antimicrobial at 88% against UpToDate's 28%. Sanford Guide Antimicrobial also leads on rating (4.8 vs 3.6) and chart position (#6 vs unranked). UpToDate's advantage is in-app purchases (none vs 3). On price, ads, monetization model and device support there is nothing between them.

Both are free to download. Sanford Guide Antimicrobial sells 3 in-app purchases, starting at $4.99 per year. UpToDate asks for nothing beyond the download.

Sanford Guide Antimicrobial holds the better App Store score, 4.8 against 3.6. Both are backed by a comparable volume of ratings — 586 and 1.9K respectively. Written reviews point the same way: 28% of UpToDate's written reviews are positive against 88% of Sanford Guide Antimicrobial's.

UpToDate ships an update every 5 weeks, Sanford Guide Antimicrobial every 2 weeks. Both last shipped on November 6, 2026.

## The numbers

| Metric | UpToDate | Sanford Guide Antimicrobial |
| --- | --- | --- |
| Price | Free | Free |
| Rating | [3.6 (586 ratings)](https://appshunter.io/ios/app/uptodate/id334265345/reviews) | **[4.8 (1.9K ratings)](https://appshunter.io/ios/app/sanford-guide-antimicrobial/id863196620/reviews)** |
| Number of ratings | 586 | **1.9K** |
| Positive reviews | 28.2% of reviews | **88.4% of reviews** |
| In-app purchases | **No** | Yes |
| Ads | No | No |
| Update frequency | Every 5 weeks | **Every 2 weeks** |
| Monetization | Subscription | Subscription |
| Best chart rank | — | **#6** |
| Size | 56 MB | 46 MB |
| Requires iOS | 18.0 | **15.0** |
| Devices | iPhone, iPad | **iPhone, iPad, iPod** |
| Age rating | 17+ | 17+ |
| Developer | [UpToDate, Inc.](https://appshunter.io/developer/334265348) | [Antimicrobial Therapy, Inc.](https://appshunter.io/developer/443442554) |

## What reviewers say

### UpToDate

[App page](https://appshunter.io/ios/app/uptodate/id334265345)

This clinical decision support tool provides healthcare professionals with evidence-based guidance to improve patient care. It features AI-powered conversational answers, continuously updated medical content, and tools for drug reference, calculations, and patient education.

**Highlights:** Expert AI conversational guidance, Gold standard clinical content, Practice-changing updates, Patient education materials, Drug reference and interactions, Clinical calculators, Kidney dosing guidance

**Features:** Vision Pro support

**In-app purchases:** none

**What reviewers like**

- 💎 Invaluable medical resource
- 🚀 Quick and easy to use
- 🔍 Comprehensive and up-to-date content

**What reviewers complain about**

- 🐛 Frequent crashes and freezing issues
- 🔌 Unreliable offline functionality
- 💰 Expensive subscription cost

**Reported bugs**

- Inability to download offline content
- Constant need to re-authenticate
- Incompatibility with recent iOS updates

**Requested features**

- Highlight and annotate content
- Improved institutional login support
- Dark mode and font size options


### Sanford Guide Antimicrobial

[App page](https://appshunter.io/ios/app/sanford-guide-antimicrobial/id863196620)

**Currently charting:** #6 Top Grossing · Medical (US App Store)

Provides clinicians with concise, evidence-based answers for infectious disease treatment decisions. Features interactive tools like spectra charts and calculators, updated frequently by an expert editorial team.

**Highlights:** Clinically actionable answers, Institutionally diverse editorial team, Constant updates, Interactive antibacterial spectra chart, Drug-drug interaction checker, Trustworthy calculators for dosing

**Features:** Vision Pro support

**In-app purchases (3)**

| Purchase | Price | Billing |
| --- | --- | --- |
| U.S. Vaccine Guidelines | $4.99 | per year |
| Sanford Guide | $39.99 | per year |
| Sanford Guide All Access | $79.99 | per year |

**What reviewers like**

- 👍 Easy to use
- 🚀 Quick access to information
- 💡 Helpful charts and tables
- 🔍 Comprehensive coverage of infections and treatments
- 📚 Up-to-date content and frequent updates

**What reviewers complain about**

- 🐛 Occasional crashes or freezing
- ⏱️ Slow search function
- 💰 Expensive subscription model
- 🔒 Login issues and subscription verification problems

**Reported bugs**

- App freezing or closing unexpectedly
- Login and subscription verification problems
- Corrupted passwords and inability to reset

**Requested features**

- Side-by-side antibiotic susceptibility comparison
- Offline access to content
- Improved navigation and UI


## Frequently asked questions

### Is UpToDate free?

UpToDate is free to download, with no in-app purchases.

### Is Sanford Guide Antimicrobial free?

Sanford Guide Antimicrobial is free to download, with in-app purchases available.

### Which has better reviews, UpToDate or Sanford Guide Antimicrobial?

Sanford Guide Antimicrobial is rated higher. UpToDate averages 3.6 out of 5 from 586 ratings, while Sanford Guide Antimicrobial averages 4.8 from 1.9K ratings.

### Do UpToDate or Sanford Guide Antimicrobial have ads?

Neither UpToDate nor Sanford Guide Antimicrobial shows ads.

### Which is updated more often, UpToDate or Sanford Guide Antimicrobial?

UpToDate ships an update every 5 weeks, and Sanford Guide Antimicrobial every 2 weeks. Most recently, UpToDate was updated on November 6, 2026 and Sanford Guide Antimicrobial on November 6, 2026.

---

*Compared by [AppsHunter](https://appshunter.io/) from daily US App Store data. Review summaries are generated from verbatim App Store reviews.*