# CTCAE v4.0 vs CTCAE 5 Pro

The clearest difference is rating: CTCAE 5 Pro at 4.8 against CTCAE v4.0's 3.5. CTCAE 5 Pro also leads on update cadence (every 5 weeks vs every 44 months) and ratings volume (38 vs 11). CTCAE v4.0's advantage is in-app purchases (none vs 2) and review sentiment (17% vs 0%). On price, ads and device support there is nothing between them.

Both are free to download. CTCAE 5 Pro sells 2 in-app purchases, starting at $1.99 per month. CTCAE v4.0 asks for nothing beyond the download.

CTCAE 5 Pro holds the better App Store score, 4.8 against 3.5. Both are backed by a comparable volume of ratings — 11 and 38 respectively. Written reviews complicate that: 17% of CTCAE v4.0's written reviews are positive against 0% of CTCAE 5 Pro's, so the app with the better star average is not the one people write more warmly about.

CTCAE v4.0 ships an update every 44 months, CTCAE 5 Pro every 5 weeks. The most recent releases landed on October 10, 2026 and October 21, 2026 respectively.

## The numbers

| Metric | CTCAE v4.0 | CTCAE 5 Pro |
| --- | --- | --- |
| Price | Free | Free |
| Rating | [3.5 (11 ratings)](https://appshunter.io/ios/app/ctcae-v40/id378487242/reviews) | **[4.8 (38 ratings)](https://appshunter.io/ios/app/ctcae-5-pro/id1625569535/reviews)** |
| Number of ratings | 11 | **38** |
| Positive reviews | **16.7% of reviews** | 0.0% of reviews |
| In-app purchases | **No** | Yes |
| Ads | No | No |
| Update frequency | Every 44 months | **Every 5 weeks** |
| Monetization | **Free** | Freemium |
| Size | 3 MB | 60 MB |
| Requires iOS | **9.2** | 15.5 |
| Devices | iPhone, iPod | **iPhone, iPad, iPod** |
| Age rating | 12+ | 17+ |
| Developer | [The Children's Hospital of Philadelphia](https://appshunter.io/developer/351401975) | [Koichiro Watanabe](https://appshunter.io/developer/1077985400) |

## What reviewers say

### CTCAE v4.0

[App page](https://appshunter.io/ios/app/ctcae-v40/id378487242)

This medical reference app provides a standardized system for grading the severity of adverse events related to drug treatments or medical devices. It offers hierarchical navigation, bookmarking, and search functionality for quick access to definitions and grading standards.

**Highlights:** Standardized adverse event grading system, Definitions for event severity (grades 1-5), Hierarchical navigation of categories, Bookmark frequently used events, Search across names, definitions, and grades

**Features:** macOS Compatibility

**In-app purchases:** none


### CTCAE 5 Pro

[App page](https://appshunter.io/ios/app/ctcae-5-pro/id1625569535)

This app helps review and take notes on CTCAE documents. It offers local data storage for privacy and premium features like version comparison and advanced note-taking with a subscription.

**Highlights:** Streamlined CTCAE Document Access, Local data storage for enhanced privacy, Version comparison tool, Advanced chronological note-taking with hashtags, Custom app creation from spreadsheets, Flexible backup and archiving (XLSX, CSV)

**Features:** macOS Compatibility, Family Sharing, Vision Pro support

**In-app purchases (2)**

| Purchase | Price | Billing |
| --- | --- | --- |
| Monthly subscription | $1.99 | per month |
| Annual subscription | $9.99 | per year |


## Frequently asked questions

### Is CTCAE v4.0 free?

CTCAE v4.0 is free to download, with no in-app purchases.

### Is CTCAE 5 Pro free?

CTCAE 5 Pro is free to download, with in-app purchases available.

### Which has better reviews, CTCAE v4.0 or CTCAE 5 Pro?

CTCAE 5 Pro is rated higher. CTCAE v4.0 averages 3.5 out of 5 from 11 ratings, while CTCAE 5 Pro averages 4.8 from 38 ratings.

### Do CTCAE v4.0 or CTCAE 5 Pro have ads?

Neither CTCAE v4.0 nor CTCAE 5 Pro shows ads.

### Which is updated more often, CTCAE v4.0 or CTCAE 5 Pro?

CTCAE v4.0 ships an update every 44 months, and CTCAE 5 Pro every 5 weeks. Most recently, CTCAE v4.0 was updated on October 10, 2026 and CTCAE 5 Pro on October 21, 2026.

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*Compared by [AppsHunter](https://appshunter.io/) from daily US App Store data. Review summaries are generated from verbatim App Store reviews.*