# CTCAE v4.0 vs NCCN Guidelines®

The clearest difference is update cadence: NCCN Guidelines® at every 2 months against CTCAE v4.0's every 44 months. CTCAE v4.0's advantage is iOS requirement (9.2 vs 13.1). On price, rating, review sentiment and ratings volume there is nothing between them.

Both are free to download. Neither carries in-app purchases, so what you see is what you pay.

On the App Store both sit at effectively the same score — 3.5 for CTCAE v4.0 against 3.6 for NCCN Guidelines®. Both are backed by a comparable volume of ratings — 11 and 24 respectively. Written reviews are what separate them: 17% of CTCAE v4.0's written reviews are positive against 13% of NCCN Guidelines®'s.

CTCAE v4.0 ships an update every 44 months, NCCN Guidelines® every 2 months. The most recent releases landed on September 24, 2026 and October 14, 2026 respectively.

## The numbers

| Metric | CTCAE v4.0 | NCCN Guidelines® |
| --- | --- | --- |
| Price | Free | Free |
| Rating | [3.5 (11 ratings)](https://appshunter.io/ios/app/ctcae-v40/id378487242/reviews) | **[3.6 (24 ratings)](https://appshunter.io/ios/app/nccn-guidelines/id775500217/reviews)** |
| Number of ratings | 11 | **24** |
| Positive reviews | **16.7% of reviews** | 12.5% of reviews |
| In-app purchases | No | No |
| Ads | No | No |
| Update frequency | Every 44 months | **Every 2 months** |
| Monetization | Free | Free |
| Size | 3 MB | 118 MB |
| Requires iOS | **9.2** | 13.1 |
| Devices | iPhone, iPod | **iPhone, iPad, iPod** |
| Age rating | 12+ | 17+ |
| Developer | [The Children's Hospital of Philadelphia](https://appshunter.io/developer/351401975) | [National Comprehensive Cancer Network®](https://appshunter.io/developer/1168594705) |

## What reviewers say

### CTCAE v4.0

[App page](https://appshunter.io/ios/app/ctcae-v40/id378487242)

This medical reference app provides a standardized system for grading the severity of adverse events related to drug treatments or medical devices. It offers hierarchical navigation, bookmarking, and search functionality for quick access to definitions and grading standards.

**Highlights:** Standardized adverse event grading system, Definitions for event severity (grades 1-5), Hierarchical navigation of categories, Bookmark frequently used events, Search across names, definitions, and grades

**Features:** macOS Compatibility

**In-app purchases:** none


### NCCN Guidelines®

[App page](https://appshunter.io/ios/app/nccn-guidelines/id775500217)

This app provides healthcare professionals with convenient access to comprehensive clinical practice guidelines for oncology. It aims to improve the quality and effectiveness of cancer care by offering evidence-based recommendations for diagnosis, treatment, and supportive services.

**Highlights:** Virtual Library of NCCN Guidelines, Oncology clinical practice guidelines, Evidence-based recommendations, Supports cancer care decision-making, Covers 97% of US cancer cases

**Features:** Vision Pro support

**In-app purchases:** none


## Frequently asked questions

### Is CTCAE v4.0 free?

CTCAE v4.0 is free to download, with no in-app purchases.

### Is NCCN Guidelines® free?

NCCN Guidelines® is free to download, with no in-app purchases.

### Which has better reviews, CTCAE v4.0 or NCCN Guidelines®?

NCCN Guidelines® is rated higher. CTCAE v4.0 averages 3.5 out of 5 from 11 ratings, while NCCN Guidelines® averages 3.6 from 24 ratings.

### Do CTCAE v4.0 or NCCN Guidelines® have ads?

Neither CTCAE v4.0 nor NCCN Guidelines® shows ads.

### Which is updated more often, CTCAE v4.0 or NCCN Guidelines®?

CTCAE v4.0 ships an update every 44 months, and NCCN Guidelines® every 2 months. Most recently, CTCAE v4.0 was updated on September 24, 2026 and NCCN Guidelines® on October 14, 2026.

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*Compared by [AppsHunter](https://appshunter.io/) from daily US App Store data. Review summaries are generated from verbatim App Store reviews.*