# CTCAE v4.0 (EN/JA) Edition vs ESMO Interactive Guidelines

The clearest difference is in-app purchases: ESMO Interactive Guidelines at none against CTCAE v4.0 (EN/JA) Edition's 1. On price, update cadence, ads and device support there is nothing between them.

Both are free to download. CTCAE v4.0 (EN/JA) Edition sells 1 one-off in-app purchase. ESMO Interactive Guidelines asks for nothing beyond the download.

CTCAE v4.0 (EN/JA) Edition ships an update every 4 months, ESMO Interactive Guidelines every 6 months. The most recent releases landed on October 18, 2026 and October 15, 2026 respectively.

## The numbers

| Metric | CTCAE v4.0 (EN/JA) Edition | ESMO Interactive Guidelines |
| --- | --- | --- |
| Price | Free | Free |
| Rating | — | **[4.8 (150 ratings)](https://appshunter.io/ios/app/esmo-interactive-guidelines/id1037353712/reviews)** |
| Number of ratings | — | **150** |
| Positive reviews | — | 80.0% of reviews |
| In-app purchases | Yes | **No** |
| Ads | No | No |
| Update frequency | **Every 4 months** | Every 6 months |
| Monetization | — | Free |
| Size | 17 MB | 195 MB |
| Requires iOS | 12.0 | 12.0 |
| Devices | iPhone, iPad, iPod | iPhone, iPad, iPod |
| Age rating | 12+ | 12+ |
| Developer | [TAKAFUMI MIZUGUCHI](https://appshunter.io/developer/400743346) | [European Society for Medical Oncology - ESMO](https://appshunter.io/developer/515544538) |

## What reviewers say

### CTCAE v4.0 (EN/JA) Edition

[App page](https://appshunter.io/ios/app/ctcae-v40-enja-edition/id576215567)

**Features:** macOS Compatibility

**In-app purchases (1)**

| Purchase | Price | Billing |
| --- | --- | --- |
| Remove Ads | $3.99 | one-time |


### ESMO Interactive Guidelines

[App page](https://appshunter.io/ios/app/esmo-interactive-guidelines/id1037353712)

Access concise, practical treatment recommendations based on the latest scientific research. This app provides interactive tools, algorithms, and calculators to support healthcare professionals in decision-making and guideline navigation.

**Highlights:** Concise treatment recommendations, Interactive decision-making tools, Treatment algorithms and calculators, Keyword search functionality, Bookmarking and note-taking, News and push notifications

**Features:** macOS Compatibility, Vision Pro support

**In-app purchases:** none


## Frequently asked questions

### Is CTCAE v4.0 (EN/JA) Edition free?

CTCAE v4.0 (EN/JA) Edition is free to download, with in-app purchases available.

### Is ESMO Interactive Guidelines free?

ESMO Interactive Guidelines is free to download, with no in-app purchases.

### Do CTCAE v4.0 (EN/JA) Edition or ESMO Interactive Guidelines have ads?

Neither CTCAE v4.0 (EN/JA) Edition nor ESMO Interactive Guidelines shows ads.

### Which is updated more often, CTCAE v4.0 (EN/JA) Edition or ESMO Interactive Guidelines?

CTCAE v4.0 (EN/JA) Edition ships an update every 4 months, and ESMO Interactive Guidelines every 6 months. Most recently, CTCAE v4.0 (EN/JA) Edition was updated on October 18, 2026 and ESMO Interactive Guidelines on October 15, 2026.

---

*Compared by [AppsHunter](https://appshunter.io/) from daily US App Store data. Review summaries are generated from verbatim App Store reviews.*