# Cytokine vs Plexus Rhythm

The clearest difference is in-app purchases: Plexus Rhythm at none against Cytokine's 4. Plexus Rhythm also leads on update cadence (every 2 weeks vs every 3 months) and iOS requirement (13.0 vs 15.1). On price, ads and device support there is nothing between them.

Both are free to download. Cytokine sells 4 one-off in-app purchases. Plexus Rhythm asks for nothing beyond the download.

Cytokine ships an update every 3 months, Plexus Rhythm every 2 weeks. Both last shipped on October 27, 2026.

## The numbers

| Metric | Cytokine | Plexus Rhythm |
| --- | --- | --- |
| Price | Free | Free |
| Positive reviews | — | 0.0% of reviews |
| In-app purchases | Yes | **No** |
| Ads | No | No |
| Update frequency | Every 3 months | **Every 2 weeks** |
| Size | 36 MB | 37 MB |
| Requires iOS | 15.1 | **13.0** |
| Devices | iPhone, iPad, iPod | iPhone, iPad, iPod |
| Age rating | 17+ | 17+ |
| Developer | [Make Differentials](https://appshunter.io/developer/1655097872) | [ADRPlexus Pvt Ltd](https://appshunter.io/developer/1458521748) |

## What reviewers say

### Cytokine

[App page](https://appshunter.io/ios/app/cytokine/id6444517018)

**Features:** Vision Pro support

**In-app purchases (4)**

| Purchase | Price | Billing |
| --- | --- | --- |
| Pro Plan \| Primary Care | $24.99 | one-time |
| Super Plan | $29.99 | one-time |
| The Surgical Blueprint | $29.99 | one-time |
| Pro Plan | $39.99 | one-time |


### Plexus Rhythm

[App page](https://appshunter.io/ios/app/plexus-rhythm/id6469149333)

**Features:** Vision Pro support

**In-app purchases:** none


## Frequently asked questions

### Is Cytokine free?

Cytokine is free to download, with in-app purchases available.

### Is Plexus Rhythm free?

Plexus Rhythm is free to download, with no in-app purchases.

### Do Cytokine or Plexus Rhythm have ads?

Neither Cytokine nor Plexus Rhythm shows ads.

### Which is updated more often, Cytokine or Plexus Rhythm?

Cytokine ships an update every 3 months, and Plexus Rhythm every 2 weeks. Most recently, Cytokine was updated on October 27, 2026 and Plexus Rhythm on October 27, 2026.

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*Compared by [AppsHunter](https://appshunter.io/) from daily US App Store data. Review summaries are generated from verbatim App Store reviews.*