# Substância P vs EpoRegen

The clearest difference is update cadence: EpoRegen at every 3 months against Substância P's every 14 months. On price, ads, in-app purchases and device support there is nothing between them.

Both are free to download. Neither carries in-app purchases, so what you see is what you pay.

Substância P ships an update every 14 months, EpoRegen every 3 months. The most recent releases landed on October 24, 2026 and October 25, 2026 respectively.

## The numbers

| Metric | Substância P | EpoRegen |
| --- | --- | --- |
| Price | Free | Free |
| In-app purchases | No | No |
| Ads | No | No |
| Update frequency | Every 14 months | **Every 3 months** |
| Size | 49 MB | 94 MB |
| Requires iOS | 16.4 | **15.0** |
| Devices | iPhone, iPad | **iPhone, iPad, iPod** |
| Age rating | 4+ | 17+ |
| Developer | [Eterno Media Marketing LTDA](https://appshunter.io/developer/1653824858) | [EpoRegen](https://appshunter.io/developer/1896310627) |

## What reviewers say

### Substância P

[App page](https://appshunter.io/ios/app/substancia-p/id6446948255)

**Features:** macOS Compatibility

**In-app purchases:** none


### EpoRegen

[App page](https://appshunter.io/ios/app/eporegen/id6766640047)

**Features:** macOS Compatibility, Vision Pro support

**In-app purchases:** none


## Frequently asked questions

### Is Substância P free?

Substância P is free to download, with no in-app purchases.

### Is EpoRegen free?

EpoRegen is free to download, with no in-app purchases.

### Do Substância P or EpoRegen have ads?

Neither Substância P nor EpoRegen shows ads.

### Which is updated more often, Substância P or EpoRegen?

Substância P ships an update every 14 months, and EpoRegen every 3 months. Most recently, Substância P was updated on October 24, 2026 and EpoRegen on October 25, 2026.

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*Compared by [AppsHunter](https://appshunter.io/) from daily US App Store data. Review summaries are generated from verbatim App Store reviews.*