# O'Neal Directory vs IOTOX Algorithm

The clearest difference is iOS requirement: O'Neal Directory at 12.4 against IOTOX Algorithm's 18.0. On price, update cadence, ads and in-app purchases there is nothing between them.

Both are free to download. Neither carries in-app purchases, so what you see is what you pay.

O'Neal Directory ships an update every 5 weeks, IOTOX Algorithm every 6 weeks. The most recent releases landed on November 8, 2026 and October 30, 2026 respectively.

## The numbers

| Metric | O'Neal Directory | IOTOX Algorithm |
| --- | --- | --- |
| Price | Free | Free |
| Rating | — | **[5.0 (1 ratings)](https://appshunter.io/ios/app/iotox-algorithm/id6744123485/reviews)** |
| Number of ratings | — | **1** |
| In-app purchases | No | No |
| Ads | No | No |
| Update frequency | **Every 5 weeks** | Every 6 weeks |
| Monetization | — | Free |
| Size | 68 MB | 7 MB |
| Requires iOS | **12.4** | 18.0 |
| Devices | **iPhone, iPod** | iPhone |
| Age rating | 4+ | 17+ |
| Developer | [UAB Health System](https://appshunter.io/developer/1293309181) | [MD Anderson Cancer Center](https://appshunter.io/developer/618340093) |

## What reviewers say

### O'Neal Directory

[App page](https://appshunter.io/ios/app/oneal-directory/id6502644980)

**Features:** macOS Compatibility

**In-app purchases:** none


### IOTOX Algorithm

[App page](https://appshunter.io/ios/app/iotox-algorithm/id6744123485)

This app provides clinical management algorithms for evaluating, diagnosing, and treating toxicities associated with cancer immunotherapies. It guides physicians on best practices for managing side effects that can arise during cancer treatment.

**Highlights:** Clinical management algorithms, Evaluation of toxicities, Diagnosis of side effects, Treatment of immunotherapy toxicities, Best practices for patient care

**Features:** macOS Compatibility, Vision Pro support

**In-app purchases:** none


## Frequently asked questions

### Is O'Neal Directory free?

O'Neal Directory is free to download, with no in-app purchases.

### Is IOTOX Algorithm free?

IOTOX Algorithm is free to download, with no in-app purchases.

### Do O'Neal Directory or IOTOX Algorithm have ads?

Neither O'Neal Directory nor IOTOX Algorithm shows ads.

### Which is updated more often, O'Neal Directory or IOTOX Algorithm?

O'Neal Directory ships an update every 5 weeks, and IOTOX Algorithm every 6 weeks. Most recently, O'Neal Directory was updated on November 8, 2026 and IOTOX Algorithm on October 30, 2026.

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*Compared by [AppsHunter](https://appshunter.io/) from daily US App Store data. Review summaries are generated from verbatim App Store reviews.*