Spearhead Calculator

SPEARHEAD is a research tool designed to explore and predict individual response to spironolactone therapy in patients with heart failure with preserved ejection fraction (HFpEF). Built on a gradient-boosting (XGBoost) model, it provides individualized estimates of treatment effect for research and validation purposes. It is powered by the model presented in the following study: 10.1016/j.ebiom.2023.104795. Disclaimer This application is intended solely for research and scientific validation purposes. It does not provide medical diagnosis or treatment recommendations. Users must not rely on the results for clinical decisions and should always seek professional medical advice before making any medical or therapeutic decision.