Stroke Drugs Ref

IMPORTANT: This app is intended for use by qualified healthcare professionals only. Always seek the advice of a qualified clinician before making any medical or prescribing decisions. Stroke Drugs Ref is a comprehensive evidence-based stroke pharmacology reference for neurologists, stroke physicians, emergency doctors, nurses and allied health professionals. Built for the stroke unit, emergency department and outpatient clinic. THROMBOLYSIS Complete alteplase and tenecteplase protocols with dosing calculators: - Alteplase: 0.9 mg/kg IV (max 90mg) - bolus and infusion protocol - Tenecteplase: 0.25 mg/kg IV bolus - AcT trial 2022, now preferred in many centres - Eligibility criteria including wake-up stroke (WAKE-UP trial) and extended window (EXTEND trial) - Absolute and relative contraindications with risk-benefit guidance - Complications: symptomatic ICH reversal protocol, angioedema management ANTIPLATELET THERAPY - Aspirin 300mg acute loading - IST/CAST evidence - DAPT protocol: aspirin + clopidogrel 21 days for TIA/minor stroke (POINT, CHANCE, THALES trials) - Clopidogrel - NICE NG128 preferred long-term agent, CYP2C19 interaction guidance - Ticagrelor: THALES trial, CYP2C19-independent, dyspnoea counse Dr Atif Elnil MBBS MRCP Neurology St Georges London UK