BioStep vs Captisol AR

The BioStep app is a professional ordering tool that allows licensed healthcare providers to capture 3D foot scans and submit orders for custom foot orthotics and AFOs fabricated by BioStep Inc. Providers can customize orders with complete product descriptions and images of every product. This app is intended exclusively for use by licensed healthcare professionals, including Podiatrists, Orthotists, Prosthetists, and Chiropractors. It is not intended for patient self-use and does not provide diagnoses, health measurements, or treatment advice. All clinical specifications are determined and entered by the treating provider. BioStep custom foot orthotics and AFOs are Class I devices, exempt from FDA premarket notification under 21 CFR 890.3475, and are intended for distribution within the United States. Disclaimer: This app is a professional ordering tool and is not a substitute for professional medical judgment. Patients should always seek the advice of a physician or qualified healthcare provider regarding any medical condition and before making any medical decisions. Note: A User Name and Password issued by BioStep is required to access the app.

Captisol is a beta-cyclodextrin with an average of 7 sulfobutylether (SBE) substitutions per molecule that was rationally designed to improve the solubility, stability, bioavailability and dosing of biologically active compounds. Ollomol AR for Captisol was designed to visualize in 3D-AR a number of Captisol-based supramolecular complexes. It allows viewing in an immersive way the movement of the structures at atomic resolution, explicitly considering all the classical degrees of freedom. The movies were generated by Molecular Dynamics simulations using the GROMACS software and the GROMOS force field with a specific parameterization for Captisol (considering a structure with four SBE groups positioned on the C6-OH of alternating glucose rings and three additional SBE groups placed on the C3-OH of the remaining glucose rings of the cyclodextrin).