ASTCT Practice Guidelines vs CARTOX

ASTCT practice guidelines and clinical calculators for blood and bone marrow transplantation, and cellular therapies. The ASTCT Practice Guidelines application provides up to date access to practice guidelines, evidence-based reviews and position statements from the ASTCT Committee on Practice Guidelines. These documents are developed and updated by leading experts in the field of blood and bone marrow transplantation and cellular therapy. In addition the app includes clinical calculators relevant to HCT patients. These tools will allow immediate access to information that can help guide clinical decision making. Topics covered include: • General guidelines • Conditioning regimens • Stem cell collection and mobilization • Graft-Versus-Host disease • HCT for Malignant and non-Malignant Hematologic Diseases, including pediatric and adult patients • Supportive Care • Survivorship Detailed references and full access to source papers is also provided. The American Society for Transplantation and Cellular Therapy (ASTCT) is an international professional membership association of physicians, investigators and other health care professionals, dedicated to improving the application and success of blood and marrow transplantation and related cellular therapies.

Cellular therapies can be associated with unique, acute toxicities which can be severe or even fatal if not identified early and treated appropriately. Cytokine Release Syndrome (CRS), the most commonly observed toxicity can range in severity from low-grade constitutional symptoms to high-grade syndrome associated with life-threatening multi-organ disfunction. Neurotoxicity, originally termed CRES (CAR-Related Encephalopathy Syndrome) and now updated to ICANS (Immune effector Cell-Associated Neurotoxicity Syndrome) is the second most-common adverse even and can occur concurrently with CRS. A multi-disciplinary working group was formed to address safety issues for patients receiving cellular therapy which led to the development of new grading methods and treatment algorithms that have been incorporated into the CARTOX mobile app. The CARTOX mobile app assists with grading toxicities, managing toxicities and assists with recommendations regarding appropriate antimicrobial prophylaxis for patients who have received immune effector cell therapy. Users are more easily able to determine if the patient is having cytokine release syndrome or neurotoxicity and to grade those toxicities. Intended audience: Clinicians (physicians, nurse practitioners, physician assistants, pharmacists, nurses) who treat/care for patients receiving immune effector cells.