HIV vs Syphilis Tools

Application Description: This application was developed with funding from the Northeast/Caribbean AIDS Education and Training Center Program and was designed for practicing clinicians to provide information on HIV medications and drug interactions with commonly co-prescribed primary care medications and HIV-HIV combinations. The four tabs at the bottom of the application include: HIV-Primary Care Interactions, HIV-HIV Interactions, Drug Metabolism, and Common Web Resources. The Common Web Resources tab contains links to external websites and phone numbers for information and national warmlines that provide clinical support with HIV care, substance use, Hepatitis C, and COVID-19. The data set for the drug interaction output for this application was developed using the Department of Health and Human Services Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV and other various sources. The application was developed and launched under the direction of VirologyEd Consultants, LLC. Disclaimer: The information contained in this application has been developed from various resources, however majority of information is from the DHHS HIV Guidelines referenced below. While the information contained in this has been reviewed, users should be aware that there may be contraindicated or combinations that may lead to adverse events that are not contained here. As with any drug interaction resource, providers are encouraged to consult additional references to verify information prior to making clinical decisions. These guidelines are for informational purposes only and cannot identify medical risks specific to an individual patient or recommend patient treatment. The absence of typographical errors is not guaranteed. These guidelines are not necessarily all-inclusive. Use of these guidelines indicates acknowledgement that neither Northeast/Caribbean AETC, nor the authors will be responsible for any loss or injury, sustained in connection with, or as a result of, the use of these guidelines. Users of this guide should consult other sources before prescribing medications or treatment. HRSA disclosure: Funding for this presentation was made possible by TR753197 from the Health Resources and Services Administration’s HIV/AIDS Bureau. The views expressed do not necessarily reflect the official policies of the Department of Health and Human Services nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. Any trade/brand names for products mentioned during this presentation are for training and identification purposes only.

The Syphilis Tools application is designed to give health care professionals, public health workers, and medical trainees relevant information and tools to help diagnose, treat, and prevent syphilis. Content is based on CDC STI Treatment Guidelines. It was developed for the National STD Curriculum (NSTDC) by the University of Washington Infectious Diseases Education & Assessment (IDEA) Program. The application addresses six primary areas: Screening: Information on screening recommendations for various patient populations. The Geographic Risk Tool allows users to quickly find county-level rates of primary and secondary syphilis in the United States and view syphilis screening recommendations. Serologic Testing: Users learn about the variety of tests and how to choose the appropriate test to order; interpret serologic tests results; and test cerebrospinal fluid. Reference materials for interpreting traditional and reverse syphilis screening algorithms are available. To help explain syphilis in a person with prior treatment, the Nontreponemal Titer Tool compares pretreatment and current treatment RPR or VDRL titers and interprets the results. Staging: Clinical criteria for understanding primary, secondary, latent, and tertiary syphilis and how to stage a patient. To help identify different manifestations, scientifically accurate medical illustrations are embedded in various sections. Treatment: Educational summaries of guideline-based medication regimens to treat stages and types of syphilis. How to treat individuals who are penicillin-allergic and/or pregnant are also addressed. Users can select multiple stages and types to explore the potential impacts on possible treatment regimens. Monitoring: Reference information on evaluating serologic response and titer changes. Users can select RPR or VDRL titers and review possible test interpretations via the Nontreponemal Titer Tool. Partner Management: Educational materials and guidance regarding the management of symptomatic and asymptomatic partners of persons diagnosed with syphilis. Features: • Content based directly on CDC STI Treatment Guidelines • Offline accessibility for use in environments without internet connection • Plain-text summaries and reference materials • Tools to help determine county-base geographic risk and compare changes in titers before and during treatment The application links to the National Network of STD Clinical Consultation Service which provides consultations for licensed healthcare professionals and STD program staff. ############### Medical Disclaimer ############### Syphilis Tools is an educational reference for health care providers. It is not a substitute for professional medical advice. Any person using this app should seek the advice of a physician or other qualified health care provider in addition to using this app before making any medical decisions.