Comparison

Synt® vs Epistemis

Price, ratings, monetisation and update history for both apps, side by side — with what reviewers say about each.

Head to head
About

Synt®

This clinical super app synthesizes patient-specific medical information, offering diagnostic decision support and dynamic data for physicians. It aids in diagnosis by augmenting human intelligence with structured medical knowledge and analytics.

Highlights
  • Patient-specific medical information processing
  • Diagnostic decision support
  • Synthetic knowledge and dynamic data points
  • Integration with MediCalc® ia
  • 800+ Disease/Problem Profiles
  • 120+ Differential Diagnosis Sets
  • 1000+ Labs & Tests
Features
Read full description

ScyMed proudly introduces the new Synt® 1.3, an expert system representing the most innovative Clinical super App, for patient-specific medical information processing, synthetic knowledge and dynamic data points for reference, analytics, diagnostic decision support & patient care. In the era of information overload, rising complexity of healthcare and huge cognitive burden for physicians, the most critical challenge they encounter when making a Diagnosis is synthesizing complex patient data (hence its name). Synt® supports the Diagnostic Process achieving synergy between Human Intelligence and Intelligence Augmentation (IA) to reach Diagnostic excellence. The system is fully integrated (data level), with ScyMed's killerApp MediCalc® ia, our trusted and highly acclaimed Medical Calculator System™, with more than half a million users worldwide (since 1999). Featuring mCalx™ (1 panel, 150+ equations/scores). FEATURING: --------------------------------------- 800 Diseases/Problems PROFILES 120+ Differential Diagnosis (DDx) SETS 1000+ Labs & Tests 500+ Equations & Scores 800+ Signs & Symptoms 250+ Drugs 100,000+ DISEASE DATA POINTS (Custom, Disease-specific Flowsheets, any combination) --------------------------------------- Introductory Price: FREE (limited time) +For Physicians, Residents, Med students, PAs and NPs. +Developed by Board-certified physicians in the US. +Trusted resource with proven & reliable data processing. +Fastest & most efficient access to info +intuitive user interface +best Data synthesis & visualization +Evidence-based and fully referenced -------------------------------- DDx Expert System Synt® is a Diagnostic Intelligence Augmentation (IA & AI) application. A rules-based expert system for Clinical Diagnosis. The logic of algorithms and the medical knowledge have been manually encoded. Every bit of data has been meticulously structured and programmed. The diagnostic logic is clear and transparent (no blackbox).  Synt® doesn't rely on LLM or Natural Language Processing at this time. Data: from Static Text to Dynamic Flowsheet Synt® is a breakthrough, it changes access to a wealth of medical knowledge from the static isolated text (book, document) to a connected, custom dynamic flowsheet (software, flowchart). It allows users to visualize and compare, side-by-side, all disease information at the deepest granular level (ad lib), including Signs, Symptoms, Labs, Tests, parameters, equations, scores, etc. The user controls the panels, selects Diseases, changes views, filters data and in the DDx+™ Tool can highlight patient-specific findings for visual efficiency. Big Data. Structured. Synt® is structured 'Big Data', organized, classified, accurate, synthesized. The largest virtual medical information matrix (flowsheet) ever developed, >2 million cells (>800 diseases by >2200 S&S, Labs, Tests, parameters, eqs, scores in the rows). Cells are populated when pertinent and indicate expected findings. Content, Function & UX/UI Synt® incorporates a wealth of synthesized info & knowledge on Diseases & Problems. Data Point cells include links to disease info, pearls, definitions, dynamic tables, classifications, normall values, converters (SI), Stats, Se, Sp, etc. Synt® functionality is highly versatile, it offers multiple views of data (search, filters, selections by Dz or SLT, processing, customization, etc.). The dark UI is elegant & visually efficient, UX is superb. ------------------------- Synt® Tools: DDx+™ (Differential Diagnosis +™) From Dx to specific Dx Noso™ Tool (Disease Data Points Tool) For DDx wayfinding SLT Checkr™ (S&S, Labs, Tests Checker™ Tool) - Symptom, Sign, Lab, Test Checker From Symptom (SLT) to Dx or Drug Drug effx™ Tool (Drug effects) From Drug to symptoms (SLT) & vice versa Synt® emphasis is on Differential Diagnosis (DDx), not on the presentation, Dx (label), Rx or Management. Synt® is NOT a Diagnostic program, it is a DDx Decision Support Tool.

About

Epistemis

Features
Read full description

Epistemis is your medical study companion: guides, a real-image atlas and clinical tools in a single app that works OFFLINE. Built for medical students and for anyone preparing board exams (USMLE Step 1 and Step 2, MIR, ENARM), and useful on the ward too. GUIDES AND REVIEW • 764 guides across 40 subjects, each with three depth levels (Essential, Intermediate, Complete): the same guide adapts to whether you are in a hurry or want the detail. • 16,271 flashcards with spaced repetition (FSRS) and Anki deck import. The optimizer retunes the algorithm using your own history, on your device. • 48 guided study paths, mnemonics across 30 areas and branching clinical cases where your decisions change the outcome. • Highlighting, personal notes and a typo-tolerant search. EXAM PRACTICE • 5,103 board-style questions (2,288 MIR, 1,276 Step 1, 1,539 Step 2) with reasoning for every option, not just the correct one. 100% carry an explanation and no subject has fewer than 25. • 556 questions now show the radiograph, ECG or plate the stem talks about, taken from the app's own atlas. • Timed block exams with per-area reports and a performance curve. • More than 5,000 subject review questions, plus a mistakes notebook that brings them back when it matters. • Compare yourself with the cohort: submit a mock score —just the score— and see your percentile. Optional and off by default. REAL IMAGES AND SOUNDS • 6,803 real pieces with a teaching layer: 4,094 ECGs, 1,238 radiographs, 353 histology, 284 gross pathology, 168 dermatology, 114 anatomy plates, 38 auscultation sounds and 508 more across eight areas. Every case carries provenance, licence and an integrity fingerprint, and its editorial status is recorded in the atlas catalogue. • 38 real heart and lung auscultation sounds and layered 3D anatomy. • Every image shows its source and license. CLINICAL TOOLS • 317 calculators and scores across 27 specialties (CKD-EPI 2021, Cockcroft-Gault, CHA2DS2-VASc, Child-Pugh, NEWS2, Wells, qSOFA and more), always showing the formula and its reference. • Drug reference with 372 drugs across 21 systems, drug interactions and renal dose adjustment. • Differential diagnosis by clinical presentation, including the can't-miss diagnoses. • 34 interactive decision algorithms, lab values, a 9,659-term glossary and 1,082 symptoms with their red flags. • Emergency, consultation and OSCE station simulators. CLIO, YOUR AI TUTOR • Ask your guides: Clio answers from the app's own content and CITES where each statement comes from. • Analyzes images (an ECG, a radiograph, a lab report) and walks you through a systematic reading, step by step — up to three images per question. • Clinical Clio reasons through a case separating data, inference and uncertainty, and an audit checks it does not cite what does not exist. • Included when you sign in, with an allowance. You can also bring your own Claude, ChatGPT or Gemini key, with no limit. EVIDENCE AND RESEARCH • Source library, on-device PDF reading, PICO projects and reproducible PubMed queries. • Interpretation of RR, OR, HR, CI, ARR and NNT, plus a sensitivity/specificity and predictive-value lab. YOUR PROGRESS, WITH YOU • Works offline, always. An account is optional. • Questions and guide corrections arrive without waiting for a new app version. • With an account, your notes, cards and progress sync across devices and merge without losing anything. • No ads. No trackers. Your data is never sold or shared. — Disclaimer: Epistemis is educational and review material. It is not a medical device, it does not diagnose or prescribe, and it does not replace formal medical training, current clinical guidelines or the judgment of a healthcare professional.

Screenshots

Synt®4 screens
Epistemis4 screens

Verdict

The call

The clearest difference is update cadence: Epistemis at every 3 days against Synt®'s every 2 weeks. Synt®'s advantage is iOS requirement (13.0 vs 15.0). On price, ads, in-app purchases and device support there is nothing between them.

Scored on Price · Rating · Positive reviews · Number of ratings · Update frequency · Ads · In-app purchases · Monetization · Best chart rank · Devices · Requires iOS

CostPrice · In-app purchases · Ads · Monetization

Both are free to download. Neither carries in-app purchases, so what you see is what you pay.

UpkeepUpdate frequency

Synt® ships an update every 2 weeks, Epistemis every 3 days. The most recent releases landed on October 22, 2026 and October 31, 2026 respectively.

Scorecard2 real differences · 8 level
Synt® versus Epistemis: the parameters behind the verdict, then further details
ParameterSynt®Epistemis
PriceFreeFree
Rating5.0 (13 ratings) — better—
Positive reviews100.0% of reviews—
Number of ratings13 — better—
Update frequencyEvery 2 weeksEvery 3 days — better
AdsNoNo
In-app purchasesNoNo
MonetizationFree—
DevicesiPhone, iPad, iPodiPhone, iPad, iPod
Requires iOS13.0 — better15.0
Further details — not scored
Size84 MB540 MB
Age rating17+17+
DeveloperScyMed, IncDavid Aldana

In-app purchases

None

Synt®

No in-app purchases

None

Epistemis

No in-app purchases

Questions

Is Synt® free?
Synt® is free to download, with no in-app purchases.
Is Epistemis free?
Epistemis is free to download, with no in-app purchases.
Do Synt® or Epistemis have ads?
Neither Synt® nor Epistemis shows ads.
Which is updated more often, Synt® or Epistemis?
Synt® ships an update every 2 weeks, and Epistemis every 3 days. Most recently, Synt® was updated on October 22, 2026 and Epistemis on October 31, 2026.

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