Dimer dice vs Biochemistry+

DimerDice allows visualizing different supramolecular dimeric complexes of cyclic peptides in Augmented Reality (AR). The cyclic peptides (CPs) are composed by γ-amino acids (cis-α,γ-aminocycloalkanecarboxylic acids, γ-Acas) alternated with α-amino acids (α,γ-CPs). These peptides containing γ-Acas can be designed from the original D,L-α-CPs just by replacing any α-amino acid for a γ-Aca of equivalent chirality. For instance, L-amino acids can be replaced by (1R,3S)-isomers while the (1S,3R)-Acas would substitute the D-enantiomers. As part of an in-vitro/in-silico study carried out at Santiago de Compostela University to deeply analyze the preferred rearrangement adopted by α,γ-CPs, we explored all the possible combinations that could take place starting from two different monomers and their corresponding enantiomers.[1] This approach uses the selective N-methylation of the amide groups whose protons are not involved in hydrogen bonding interactions. The N-methylated residues are indicated in the figures of the trackers. Depending on the combination of monomers, a parallel or an antiparallel arrangement is possible. Pointing with the device to each tracker separately, an AR image of the corresponding monomer is viewed. When the tracker images of two monomers are placed close to each other, the structure of the dimer formed by that combination of cyclic peptides is shown. Full geometry optimizations of the dimers and monomers were carried out with the B3LYP functional and the standard 6-31G(d) basis set. All of the DFT calculations reported in this study were performed with the Gaussian 16 package. This application was specifically developed by Santiago de Compostela University (Spain) and MD.USE Innovative Solutions S.L. (www.mduse.com). [1] Manuscript in preparation.

Master all essential topics in Biochemistry with Fun and Engaging Quizzes! Dive into the world of Biochemistry with our comprehensive quiz app, designed to boost your knowledge, confidence, and skills. Whether you're a student, practitioner, or just exploring the field, this app is your ultimate companion for learning and growth. Topics Covered: Introduction to Biochemistry: -Definition, scope, relation to biology & chemistry -Biochemical experimental techniques Water, pH, and Buffers: -Structure and properties of water -Noncovalent interactions in biological systems -Acid–base chemistry and pH scale -Biological buffer systems (e.g., bicarbonate, phosphate) Amino Acids and Peptides: -Structure, classification, and properties of amino acids -Acid-base behavior of amino acids -Peptide bond formation and characteristics -Chemical modifications of amino acids and peptides Proteins: Structure and Function: -Levels of protein structure (primary to quaternary) -Protein folding and stability -Functional diversity of proteins (enzymes, hormones, antibodies) -Methods for protein purification and analysis Enzymes: Catalysis and Kinetics: -Mechanism of enzyme catalysis -Michaelis–Menten kinetics -Enzyme inhibition (competitive, noncompetitive, irreversible) -Allosteric regulation and enzyme control Carbohydrates: Structure and Function: -Monosaccharides and stereochemistry -Disaccharides and polysaccharides -Glycoconjugates and glycoproteins -Biological roles of carbohydrates (energy, signaling, structure) Lipids and Membranes: -Fatty acids and triacylglycerols -Phospholipids and glycolipids -Cholesterol and steroid hormones -Structure and dynamics of biological membranes Nucleic Acids: DNA and RNA: -Structure of nucleotides and nucleosides -DNA double helix and its properties -RNA structure and functional types -Nucleotides in metabolism (ATP, NADH, FAD) Bioenergetics and Metabolism: -Laws of thermodynamics in biochemistry -Free energy and coupled reactions -ATP as the universal energy currency -Overview of catabolism and anabolism Carbohydrate Metabolism: -Glycolysis and its regulation -Gluconeogenesis and reciprocal control -Glycogen metabolism (synthesis and breakdown) -Pentose phosphate pathway and its significance Lipid Metabolism: -β-oxidation of fatty acids -Ketone body formation and utilization -Lipid biosynthesis (fatty acids, triglycerides) -Cholesterol metabolism and regulation Protein and Amino Acid Metabolism: -Proteolysis and amino acid catabolism -Transamination and deamination reactions -Urea cycle and nitrogen excretion -Biosynthesis of amino acids and clinical disorders Nucleotide Metabolism: -Biosynthesis of purines -Biosynthesis of pyrimidines -Nucleotide degradation pathways -Clinical disorders (e.g., gout, SCID, orotic aciduria) Molecular Biology and Genetic Information Flow: -DNA replication mechanisms and enzymes -Transcription and RNA processing -Translation and genetic code -Regulation of gene expression (prokaryotes and eukaryotes) Biochemistry in Health: -Hormones and signal transduction pathways Who is it for? - Students preparing for exam. - Professionals brushing up on their knowledge. - Anyone interested in understanding Biochemistry. Download now and make learning Biochemistry+ enjoyable and effective! Terms of Use: https://www.apple.com/legal/internet-services/itunes/dev/stdeula/ Privacy Policy: https://forwaelade.web.app/Biochemistry/privacy-policy