ReproAnswer vs RapidASCVD

Integrating authoritative information from multiple gold-standard sources, ReproAnswer™ supports health care providers as they assess medication risk with pregnant patients. Use ReproAnswer to: • FIND authoritative information to support medication safety in pregnancy and lactation • UNDERSTAND quickly by efficiently searching for and returning topic-specific information • DECIDE on appropriate medication treatment options for pregnancy and lactation • EXPLAIN to patients and family members so they feel more comfortable with the decision Why ReproAnswer? For most medications: • the safety or risk profile is either unknown or very difficult to find • it is difficult for healthcare providers and pregnant women to weigh the risks and benefits of treatment options According to the Centers for Disease Control and Prevention (CDC): • Every infant has at least a 5% risk of being born with a serious congenital anomaly • 9 of 10 women take at least one medication during pregnancy • Medication use in pregnancy up more than 60% in last 30 years • Women struggle with decisions regarding medication use in pregnancy • Pregnant patients may discontinue or underuse needed medications due to fear • Without treatment, the woman and/or her baby could be harmed

RapidASCVD accurately estimates 10-year ASCVD (atherosclerotic cardiovascular disease). The user interface has been optimized for speed so that busy clinicians are able to quickly calculate ASCVD scores for patients in the fastest amount of time possible -- usually within about 10-15 seconds. ASCVD risk is the estimated probability of a patient having a first-time (primary) event of coronary heart disease (such as myocardial infarction), cerebrovascular disease (such as stroke), and peripheral arterial disease. This estimate is not appropriate for use in patients who have already had one of these cardiovascular events. RapidASCVD has been extensively tested for accuracy with the pooled cohort equations (2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk. doi: 10.1161/​01.cir.0000437741.48606.98), which is derived from the following variables: • Age • Total cholesterol • HDL cholesterol • Systolic blood pressure • Sex • Race • Presence of antihypertensive therapy • History of diabetes mellitus • Current smoking status The risk estimate is consistent with the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (doi: 10.1161/CIR.0000000000000678), acknowledging that many other cardiovascular risk factors exist that are not present in the ASCVD risk calculation. This clinical tool is intended to be used in conjunction with reasonable clinical judgment.