TDF Calc vs RO Toolbox

TDFCalc is an application which implements the linear-quadratic (LQ) method for comparing the biologically effective dose (BED) of external beam radiation therapy (EBRT) fractionation regimens as well as low dose rate (LDR) and permanent implant brachytherapy treatments. It calculates BED for a given alpha/beta ratio as a function of the dose per fraction and number of fractions for EBRT, and initial dose rate for brachytherapy. For a predetermined BED, the app solves the quadratic equation to calculate dose per fraction as a function of the number of fractions desired. This enables quick comparison of modified fractionation regimens (e.g. hypofractionation or compensating for missing treatment fractions) vs a conventional and/or originally intended regimen.

The RadOnc Toolbox is a resource for health care professionals that is designed to support evidence-based practice. This point-of-care tool compiles frequently accessed references related to the delivery of radiation therapy, including dose constraints, calculators, clinical practice guidelines, staging, and other oncology resources.    The RadOnc Toolbox was created by Malolan Rajagopalan, MD, MBA, who was Principal Investigator of a grant from the ASTRO Foundation, then known as the Radiation Oncology Institute (ROI), that aimed to develop a resource to manage acute and late radiation toxicity. The Foundation assumed responsibility for the RadOnc Toolbox and released the first version in 2016. Since then, the Foundation has continued to add resources and enhance the content.   The redesigned RadOnc Toolbox released by the Foundation in 2023 is produced in collaboration with Red Canvas, LLC.