cTrials vs Captisol AR

• A mobile front end for searching clinical trials listed on www.clinicaltrials.gov by National Library of Medicine  (NLM/NIH) • All of the features of www.clinicaltrials.gov website are incorporated in this app.  • Incorporates user friendly navigation schemes with Basic, Advanced, Refine  Search and Search by Country /State features • Predictive Text feature for Basic Search screen • Customizable individual personal profile feature • Empowers the end users to save a clinical trial listing to favorites folder, e-mail the clinical trial, contact an investigator • Save the ‘Search History’ and many more… • Attach a personal profile with voice memo to an Clinical Study Investigator via e-mail • Contact a Clinical Study Investigator  through the app

Captisol is a beta-cyclodextrin with an average of 7 sulfobutylether (SBE) substitutions per molecule that was rationally designed to improve the solubility, stability, bioavailability and dosing of biologically active compounds. Ollomol AR for Captisol was designed to visualize in 3D-AR a number of Captisol-based supramolecular complexes. It allows viewing in an immersive way the movement of the structures at atomic resolution, explicitly considering all the classical degrees of freedom. The movies were generated by Molecular Dynamics simulations using the GROMACS software and the GROMOS force field with a specific parameterization for Captisol (considering a structure with four SBE groups positioned on the C6-OH of alternating glucose rings and three additional SBE groups placed on the C3-OH of the remaining glucose rings of the cyclodextrin).