ImmGen vs QGenome

Explore gene expression levels in different mouse and human immune system cells. Start by entering a gene name (or alias) in the search bar to see a list of hits you can swipe through. Searching will display a "heatmap barcode" that shows how hot or cold expression of that gene is across different immune system cell lineages (B cells, T cells, Myeloid cells, etc). Toggle between 3 different datasets: mouse RNA-seq, mouse microarray, and human RNA-seq. Press down on a cell lineage icon to see the same expression data visualized as a bar chart. Use the settings menu in the top right to toggle between a log and linear axis. In the microarray data, low expression values are partially occluded. Back on the main "heatmap barcode" screen, if you instead press the "Show related genes" button, you'll see a "gene constellation" view. This shows its most correlated genes within certain population groups. By default, correlation is shown with respect to key populations — these are key populations across the entire immune system. Please reach out to immgen@gmail.com for feedback or feature requests! The data are generated by the Immunological Genome Project, an international consortium supported by the National Institutes of Health (NIAID).

QGenome has been developed by Guy's and St Thomas' NHS Foundation Trust's Regional Genetics service, a partner in the South East Genomic Medicine Service Alliance, and UBQO to provide streamlined inherited genomic risk assessment, testing and referral guidance in an accessible and user-friendly format. QGenome enables users to decide which patients may be eligible for genomic investigations and risk assessment, in line with the NHSE Genomic Test Directory and published literature. It provides clinicians with a framework of questions that can be used in their clinical approach when managing patients who are concerned about an inherited susceptibility to disease. The application allows users to access up to date clinical guidance, at the ‘point of care’, and delivers a time-efficient mechanism to instigate genomic evaluation and onward referrals, where necessary. The aim of QGenome is to facilitate streamlined quicker access to enhanced surveillance, risk-reduction options, genetic counselling, genomic testing and multidisciplinary care for patients and their families.