ApoThera vs Synt®
Price, ratings, monetisation and update history for both apps, side by side — with what reviewers say about each.
ApoThera
This app provides clinical decision support for healthcare professionals. It offers treatment recommendations, disease management tools, drug information, interaction checkers, medical calculators, and patient savings programs. Content is updated daily and covers a wide range of medical specialties.
- Clinical guidelines and treatment recommendations
- Disease management and drug information
- Drug interaction checker
- Medical calculators and conversion tools
- Patient Rx savings and discounts
- PDF document archiving
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ApoThera - Clinical Decision Support - Mobile Application ApoThera - features the following seven medical applications: 1) Clinical Guidelines • Treatment recommendations provided by peer-reviewed journals and manufacturers based on evidence-based medicine to optimize patient care 2) Disease Management • Providing treatment options for thousands of diseases and conditions based on manufacturers drug database provided by pharmaceutical manufacturers. 3) Drug Information • Providing drug information and medical reference for thousands of FDA-approved brand, generic, and OTC medicines based on drug database provided by pharmaceutical manufacturers. • Search by brand, generic or pharmacologic class names. • Drug monographs updated continuously with the latest information. 4) Drug Interaction Checker • Providing mutli-drugs interaction check with accurate clinical answers for any possible drug-drug interactions at the point of care with detail information about onset, severity warning management, mechanism, and references for all FDA-approved mechanisms. 5) ApoThera Medical Calculators & Conversion Tools • Processing clinical algorithms, calculating medical scores, scales, classifications • Cardiovascular Conversion Tool - Beta-Blockers Conversion Tool - ACE Inhibitors Conversion Tool - Angiotensins Receptor Blockers (ARBs) Conversion Tool - HMG-CoA Reductase Inhibitors (Statins) Conversion Tool - Diuretics Conversion Tool - Vasodilators Conversion Tool • Endocrinology Conversion Tool - Antidiabetics Conversion Tool - Insulin Conversion Tool - Thyroids Conversion Tool - Epoetin alfa Conversion Tool • Opioids Conversion Tool • Corticosteroids Conversion Tool • Benzodiazepines Conversion Tool • Psychoneurology Conversion Tool - Antipsychotics Conversion Tool - Antidepressants Conversion Tool - Antiepileptics Conversion Tool • Gastroenterology Conversion Tool - Proton Pump Inhibitors (PPIs) Conversion - H2 Blockers Conversion Tool • Total Parenteral Nutrition 6) PDF Box • Uploading and archiving PDF documents. 7) Patient Rx Savings • Discounts and coupons available through manufacturers for expensive biotechnology specialty medications. Medical Specialties: Anesthesiology, Cardiology & Vascular Medicine, Critical Care & Emergency Medicine, Endocrinology, Gastroenterology, Geriatric Medicine, Hematology - Oncology, Infectious Disease, Internal Medicine, Neurology, Obstetrics & Gynecology, Orthopedics, Pediatric, Psychiatric, Pulmonary Medicine, Surgery, Toxicology and Urology. • ApoThera content is updated daily.• ApoThera Premium monthly auto-renewable subscription allows full access to all calculation tools for 1 month. Payment will be charged to the user's iTunes Account at confirmation of purchase. After successful purchase, all disabled calculation tools and drug info will become active. After exactly 1 month from the subscription purchase date, the monthly subscription will renew automatically for another month at the subscription price on the date of the renewal. To cancel auto renewal, users must turn off the auto-renewal 24 hours before the renewal date by going to their iTunes account settings. Any unused portion of a free trial period will be forfeited when the user purchases a subscription. For ApoThera End User License Agreement, please visit: http://www.apothera.com/WS/GetAppInfo.aspx?Type=1
Synt®
This clinical super app synthesizes patient-specific medical information, offering diagnostic decision support and dynamic data for physicians. It aids in diagnosis by augmenting human intelligence with structured medical knowledge and analytics.
- Patient-specific medical information processing
- Diagnostic decision support
- Synthetic knowledge and dynamic data points
- Integration with MediCalc® ia
- 800+ Disease/Problem Profiles
- 120+ Differential Diagnosis Sets
- 1000+ Labs & Tests
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ScyMed proudly introduces the new Synt® 1.3, an expert system representing the most innovative Clinical super App, for patient-specific medical information processing, synthetic knowledge and dynamic data points for reference, analytics, diagnostic decision support & patient care. In the era of information overload, rising complexity of healthcare and huge cognitive burden for physicians, the most critical challenge they encounter when making a Diagnosis is synthesizing complex patient data (hence its name). Synt® supports the Diagnostic Process achieving synergy between Human Intelligence and Intelligence Augmentation (IA) to reach Diagnostic excellence. The system is fully integrated (data level), with ScyMed's killerApp MediCalc® ia, our trusted and highly acclaimed Medical Calculator System™, with more than half a million users worldwide (since 1999). Featuring mCalx™ (1 panel, 150+ equations/scores). FEATURING: --------------------------------------- 800 Diseases/Problems PROFILES 120+ Differential Diagnosis (DDx) SETS 1000+ Labs & Tests 500+ Equations & Scores 800+ Signs & Symptoms 250+ Drugs 100,000+ DISEASE DATA POINTS (Custom, Disease-specific Flowsheets, any combination) --------------------------------------- Introductory Price: FREE (limited time) +For Physicians, Residents, Med students, PAs and NPs. +Developed by Board-certified physicians in the US. +Trusted resource with proven & reliable data processing. +Fastest & most efficient access to info +intuitive user interface +best Data synthesis & visualization +Evidence-based and fully referenced -------------------------------- DDx Expert System Synt® is a Diagnostic Intelligence Augmentation (IA & AI) application. A rules-based expert system for Clinical Diagnosis. The logic of algorithms and the medical knowledge have been manually encoded. Every bit of data has been meticulously structured and programmed. The diagnostic logic is clear and transparent (no blackbox). Synt® doesn't rely on LLM or Natural Language Processing at this time. Data: from Static Text to Dynamic Flowsheet Synt® is a breakthrough, it changes access to a wealth of medical knowledge from the static isolated text (book, document) to a connected, custom dynamic flowsheet (software, flowchart). It allows users to visualize and compare, side-by-side, all disease information at the deepest granular level (ad lib), including Signs, Symptoms, Labs, Tests, parameters, equations, scores, etc. The user controls the panels, selects Diseases, changes views, filters data and in the DDx+™ Tool can highlight patient-specific findings for visual efficiency. Big Data. Structured. Synt® is structured 'Big Data', organized, classified, accurate, synthesized. The largest virtual medical information matrix (flowsheet) ever developed, >2 million cells (>800 diseases by >2200 S&S, Labs, Tests, parameters, eqs, scores in the rows). Cells are populated when pertinent and indicate expected findings. Content, Function & UX/UI Synt® incorporates a wealth of synthesized info & knowledge on Diseases & Problems. Data Point cells include links to disease info, pearls, definitions, dynamic tables, classifications, normall values, converters (SI), Stats, Se, Sp, etc. Synt® functionality is highly versatile, it offers multiple views of data (search, filters, selections by Dz or SLT, processing, customization, etc.). The dark UI is elegant & visually efficient, UX is superb. ------------------------- Synt® Tools: DDx+™ (Differential Diagnosis +™) From Dx to specific Dx Noso™ Tool (Disease Data Points Tool) For DDx wayfinding SLT Checkr™ (S&S, Labs, Tests Checker™ Tool) - Symptom, Sign, Lab, Test Checker From Symptom (SLT) to Dx or Drug Drug effx™ Tool (Drug effects) From Drug to symptoms (SLT) & vice versa Synt® emphasis is on Differential Diagnosis (DDx), not on the presentation, Dx (label), Rx or Management. Synt® is NOT a Diagnostic program, it is a DDx Decision Support Tool.
Screenshots
Verdict
The clearest difference is rating: Synt® at 5.0 against ApoThera's 4.2. Synt® also leads on in-app purchases (none vs 2) and ads (none vs shown). ApoThera's advantage is chart position (#194 vs unranked) and iOS requirement (11.0 vs 13.0). On price, ratings volume and device support there is nothing between them.
Scored on Price · Rating · Positive reviews · Number of ratings · Update frequency · Ads · In-app purchases · Monetization · Best chart rank · Devices · Requires iOS
Both are free to download. ApoThera sells 2 in-app purchases, starting at $2.99 per month. Synt® asks for nothing beyond the download.
Synt® holds the better App Store score, 5.0 against 4.2. Both are backed by a comparable volume of ratings — 14 and 13 respectively. Written reviews point the same way: 89% of ApoThera's written reviews are positive against 100% of Synt®'s.
ApoThera ships an update every 2 months, Synt® every 2 weeks. The most recent releases landed on September 7, 2026 and September 17, 2026 respectively.
| Parameter | ApoThera | Synt® |
|---|---|---|
| Price | Free | Free |
| Rating | 4.2 (14 ratings) | 5.0 (13 ratings) — better |
| Positive reviews | 88.9% of reviews | 100.0% of reviews — better |
| Number of ratings | 14 — better | 13 |
| Update frequency | Every 2 months | Every 2 weeks — better |
| Ads | Yes | No — better |
| In-app purchases | Yes | No — better |
| Monetization | Free with in-app purchases | Free — better |
| Best chart rank | #194 — better | — |
| Devices | iPhone, iPad, iPod | iPhone, iPad, iPod |
| Requires iOS | 11.0 — better | 13.0 |
| Further details — not scored | ||
| Size | 19 MB | 84 MB |
| Age rating | 17+ | 17+ |
| Developer | Apothera Inc. | ScyMed, Inc |
Customer experience
ApoThera
Synt®
In-app purchases
ApoThera
- ApoThera Monthly$2.991 Month
- ApoThera 1 year Auto-Renew7 Days trial$59.991 Year
Synt®
No in-app purchases









