HepCalc vs TherapySelector

HepCalc is a collection of liver related calculators, web links, resources, and editable web links and clinical notes. ◆ Unlike most calculators, entry data is preserved between different calculators limiting the need for reentry of data. ◆ Set your own favorite web links ◆ Save clinical notes, clinical "pearls" in a organized fashion ◆ Integrated U.S. - SI units conversion ◆ Each calculator has a related web reference A must have for the clinician/house officer dealing with liver disease. The customizable WebLinks and Clinical Notes sections alone are valuable tools for anyone. Child-Pugh Score MELD (UNOS) -survival data -TIPS recommendations MELD MELD Sodium (UNOS) MELD 3.0/Survival Alcoholic Hepatitis Calculators: - ABIC -Combined: Lille Model +(MELD, Maddrey DF, ABIC) - Glasgow - Lille Model - Lille Model Projection (using day 0 of Rx, calculates decision making for bilirubin values on day 7) - Maddrey Discriminant Function - MELD alcoholic hepatitis score ( Includes survival percentage) Autoimmune Liver Disease Calculators: -Autoimmune hepatitis Score(1999 International AIH Group Report) -Autominnune hepatitis Simplified Score -AIH/PBC overlap (Paris Criteria) -PBC Survival Mayo GLOBE UK-PBC -PSC Survival Fibrosis Calculators: - APRI Fibrosis Score - FAST (Fibroscan™ + AST) Score - FIB4 Fibrosis Score - FORNS Fibrosis Score - HALT-C Cirrhosis Score - NAFLD Fibrosis Score -SAFE Fibrosis Score (Steatosis-associated Fibrosis Estimate) Risk Assessment Calculators: Liver Decompensation - Acute decompensation without ACLF: CLIF-C AD score and mortality -Acute liver failure - transplant free survival at 21 days - Acute on Chronic Liver Failure AARC score and mortality - Acute on Chronic Liver Failure CLIF-C ACLF score and mortality - Acute on Chronic Liver Failure NACSELD 30 day mortality - BE3A Score: Hep C DAA assessment for decompensated cirrhosis - Decompensation Risk - Hep C -TAM Score: 1 yr post transplant survival for ACLF-3 patients HCC Risk Hep B - HCC Risk Hep B: CHUK - HCC Risk Hep B: REACH B - HCC Risk Hep B on Rx (entecavir, tenofovir): PAGE B HCC Risk Hep C - HCC Risk Hep C : HALT-C - HCC Risk in Chronic Liver Disease: GALAD/GALADUS Other Risks -BEA Score: Baseline event anticipation for Hepatitis Deta -Cardiovascular Risk (CAD-LT): CV risk in LT candidates - CAR-OLT: 1 yr risk of cardiovascular event post OLT -Dili Mortality Risk: 6 mos mortality risk and comorbidity burden - Fungal Infection Risk - NACSELD - RUCAM for DILI assessment - Surgical Risk Cirrhosis: post op mortality major surgery -Surgical Risk Cirrhosis: VOCAL-Penn Score Other Calculators: -ANI (differentiate between alcoholic and non-alcoholic steatohepatitis) -Ascites, refractory -estimate ascites to be gained based on serum sodium and time passed -estimate sodium intake based on serum sodium and ascites gained -Body Mass Index - Portopulmonary Hypertension Calculator: - Pulmonary Vascular Resistance Calculator -diagnostic and UNOS transplant Criteria -HCV treatment tracker (calculates dates for end of Rx and SVR) -Mean arterial pressure -Wilson's Disease: EASL scoring system WebLinks: - Hepatology Societies - Hepatology Organizations - Other Resources (i.e. Drug Hepatoxicity, Hepatitis Rx drug interactions, etc) - Custom WebLinks (make your own links for reference, frequently used, etc.) Clinical Notes: - Create a title and store clinical information, pearls, or any other text for quick ready reference in one place - Can cut and paste from other text for ease of entry of your clinical data

TherapySelector supports you as a physician to easily and quickly choose a data-based, person-centered treatment for hypertension and hepatitis C for and with your patient during consultation hours. The app shows in a single glance information about the effectiveness of medication based on the disease remission (systolic blood pressure lower than 140 mmHg for hypertension and viral clearance in hepatitis C), the likelihood of adverse events, cost and patient group size. This overview allows you to easily and quickly decide on the best person-centered treatment method for your patient, based on study data. How does TherapySelector work? First you enter the requested characteristics of your patient by answering 4 simple questions about etiology, disease stage, previous treatments and comorbidities. Based on this, a profile of the patient is determined. The app then shows an overview of all registered treatments for that specific patient profile, based on frequently updated study results. For each therapy you find information about effectiveness, possible adverse events and costs. TherapySelector currently provides the following features: • Determination of patient profiles based on four simple questions about the patient. • Probability of "success" of all registered medication (combinations) for hypertension and hepatitis C, together with the probability of adverse events associated with the patient profile, based on individual patient data from key clinical scientific studies. • For hypertension: overview of therapy options with Thiazide diuretics (THZ), Calcium Channel Blockers (CCA), ACE inhibitors (ACEi) or Angiotensin Receptor Blockers (ARB). Information on monotherapy with dose increase (Titrate), and results of stepwise addition of medication (Titrate & Add). • Detail information, including information about dosage (of the therapy regime) and the cost of a specific treatment. • Availability in both English and Dutch. TherapySelector is intended to provide physicians and patients person-centered information to support them in choosing the most appropriate treatment. In doing so, the app complements guidelines that are based on the ‘average’ patient. The TherapySelector app can be used without creating an account. Developed with (academic) medical centers and research institutes TherapySelector is developed by TherapySelector in collaboration with physicians and scientists associated with universities and leading academic medical centers such as the Erasmus MC, LUMC and MUMC+. The data in the app has been authorized by specialists from Dutch scientific associations. The results are calculated using anonymous patient data from scientific studies of published randomized controlled trials, other phase 2 & 3 studies and prospective real-life studies around the world (high quality research). Research groups and sponsors make their data available for this purpose. About TherapySelector TherapySelector B.V. is a social enterprise. Our mission is to improve health care globally by enriching it with person-centered treatment information based on the most recent data from scientific studies. It is not our goal to make profit. With the TherapySelector app, we facilitate doctors with person-centered care to achieve health gains for their patients. Additionally, we want to aid in controlling the rising costs of healthcare for the public, e.g. by preventing over- and under-treatment. Follow us on LinkedIn (https://www.linkedin.com/company/therapyselector) or visit www.therapyselector.com.