SOHO365 vs NMSC Immunotherapy Guide IAR

The Society of Hematologic Oncology (SOHO) was established as a non-profit corporation in 2012 with aims to promote worldwide research, education, prevention, clinical studies and optimal patient care in all aspects of hematologic malignancies and related disorders. Since that time, approximately 8,000 members from 110 countries have joined the society from around the globe. SOHO is a global society designed specifically for clinicians, research scientists and related health care professionals who specialize in the research and treatment of patients with hematologic malignancies. SOHO’s mission is to expedite worldwide research and education through the exchange of scientific information. Organized by its founders and world class committees, SOHO is the only society specific to this field. SOHO represents physicians and other professionals from all corners of the world. SOHO is leading vital efforts to further treatments for those with hematologic malignancies. Become a SOHO Member free-of-charge. Join us and experience the benefits of membership at http://sohoonline.org ! Mobile app features: • Instant connections to our SOHO Community of nearly 8,000 members • Access to a comprehensive Resource Center that includes slides, publications, abstracts, videos and more • Connection to our SOHO DocMatter Community for hematologic oncology discussions, questions and education • Access to our official journal, ‘Clinical Lymphoma Myeloma and Leukemia’and our news publication, 'Blood Cancers Today' • Direct access to event information and registration with significant member-only discounts • Set SOHO reminders and receive alerts within the App • Connect to the App through Facebook, LinkedIn, and Twitter

In nonmelanoma skin cancer (NMSC), particularly cutaneous squamous cell carcinoma (cSCC), treatment selection has evolved with the integration of immune checkpoint inhibitors (ICIs) across multiple stages of disease. Current guidelines support a risk-adapted approach in which ICIs play a central role for patients with high-risk, locally advanced, or metastatic disease, as well as an emerging role in earlier treatment settings. For unresectable or metastatic disease, ICIs targeting the PD-1/PD-L1 pathway are the preferred systemic therapy, offering durable responses and a favorable tolerability profile compared with traditional approaches. Their use is supported by the underlying tumor biology of cSCC, which is characterized by a high tumor mutational burden driven by ultraviolet radiation exposure. This leads to increased neoantigen formation and enhanced tumor immunogenicity, making these tumors particularly responsive to immune modulation. In addition, upregulation of immune checkpoint pathways such as PD-1/PD-L1 contributes to immune evasion, providing a strong mechanistic rationale for checkpoint blockade. Beyond advanced disease, ICIs are increasingly being incorporated into neoadjuvant and adjuvant treatment strategies for high-risk, resectable NMSC. In the neoadjuvant setting, ICIs may reduce tumor burden, improve surgical outcomes, and, in some cases, enable less extensive resections. In the adjuvant setting, they are being explored to reduce the risk of recurrence following surgery, particularly in patients with high-risk pathologic features. These approaches reflect a shift toward earlier immune intervention in the disease course.