OurVCP vs FORWARD 102

The OurVCP app is being used for a VCP app and wearable study conducted by 4YouandMe - a digital health non-profit organization in partnership with Cure VCP Disease Inc., and funded by the Chan Zuckerberg Initiative. This prototype app is 1 of 5 apps that are being tested as part of a larger rare and unique disease study that aims to co-design and pilot test symptom tracking and transmitting apps alongside wearable devices across 5 different conditions including VCP disease, Pancreatitis, Long COVID, Sarcoidosis, and Primary Ciliary disease. Each of these conditions present unique symptom profiles across individuals that span symptoms of cognitive disturbances, pain, fatigue, cough, autonomic changes, respiration changes and mental health burden that are unique to each individual. This study aims to work with participants as co-designers to beta test an app and wearable experience that is intended to work like a compass to empower individuals to follow their unique symptom trajectories in passive and active ways, better understand what makes their condition better or worse and provide more accurate information for clinicians. If you decide to participate, after having a conversation with a 4YouandMe representative, you will download this study app where you will be fully informed of the study details and sign a consent form agreeing to participate. This app will serve as a hub for study participation. Using this app, you can track your study progress, complete surveys and tasks, and connect other mobile apps and wearable/smart devices that will be provided to you that will include an Oura smartring, an Applewatch and a MIR Smart One Spirometer. You will be asked to use the study app and wear and use the provisioned devices for 5 months and communicate with a 4YouandMe Engagement Specialist every 2 weeks to discuss your experience. We expect that using the app for the study will take less than 5 minutes daily. This study has been reviewed and approved by an Institutional Review Board (Advarra).

This app is intended for use by participants in the FORWARD 102 study and requires an invitation and activation code from the study site to register. A Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of VX-880 in Subjects With Type 1 Diabetes With a Kidney Transplant. This study has been reviewed and approved by the appropriate regulatory body, e.g. Institutional Review Board (IRB) or Independent Ethics Committee (IEC). Key App Features: - Patient Onboarding – complete study app registration and education - Activities – complete scheduled or on-demand study tasks and assessments - Dashboard – review overall progress in the study and current activities - Resources – view study information in the Learn section of the app - Profile – manage account details and app settings - Notifications – receive in-app reminders - Telehealth – conduct scheduled virtual visits with your study site About THREAD: THREAD’s® purpose is to leverage its clinical research platform to enable studies for everyone, everywhere. The company’s uniquely combined clinical research technology and consulting services help life science organizations to design, operate, and scale next-generation research studies and electronic clinical outcome assessments (eCOA) programs for participants, sites, and study teams. Through its comprehensive platform and scientific expertise, THREAD empowers studies to be accessible, efficient, and centered on the patient.