TIVAinSight vs TEE Simulator 3D

TIVAinSight is a PK/PD simulator that calculates and plots the plasma (Cp) and effect-site (Ce) concentrations of intravenous anesthetics and opioids given by infusion or bolus, using a three-compartment model with an effect site. It is software for the education and research of anesthesiologists, residents and other clinicians. It is not a medical device and must not be used for dosing decisions or dosing plans in actual patients. Features - Four drugs (propofol, remimazolam, remifentanil, fentanyl) and 17 PK/PD models (Marsh, Schnider, Eleveld, Kataria, Short, Paedfusor, Minto, Kim, Rigby-Jones, Shafer, Scott, Masui, Schüttler and more) - Two drugs at once, each in Manual (rate), TCI (plasma target) or ETCI (effect-site target) mode - Boluses, per-kg bolus chips and quick chips for common targets and rates - Fast-forward from x1 to x300 (the calculation always uses a 1-second step with the classical fourth-order Runge–Kutta method) - Chart with a callout that always shows the current Cp, Ce, infusion rate and total dose (can be hidden; shows the values at the cursor when you point at a time), two Y axes, drag to pan, pinch or drag the time axis to zoom time, and scale each Y axis - Settings in tabs (left panel on the wide screen of a Mac or iPad, bottom panel on iPhone), usable without scrolling on typical screen sizes; on iPhone the chart keeps its size when you switch tabs - CSDT / CSHT: predicted time for Ce to fall by a chosen percentage or to a custom target after stopping the infusion - Presentation mode (Mac and iPad): enlarged chart, readouts, chips and CSDT for projecting in lectures and talks (full screen on Mac) - mL/h dose unit: set the syringe concentration to enter and show rates in mL/h and boluses in mL - Patient presets (adult, elderly, child, infant) and body-size indices (BMI, LBM, FFM, ...) - Verification screen: runs, on this device, the same Level-1 verification as the manuscript (43 runs, 720,092 values compared with the exact matrix-exponential solution) and 24 published reference checks - References (DOI, PMID), populations and parameters for every model - CSV export; Japanese and English interface The app follows the same calculation procedure as the web version of TIVAinSight (https://msanuki.com/TIVAinSight/) and gives the same values for the same inputs. Notes - The Cp / Ce values are model-based estimates and are not guaranteed to match measured values. - Do not use it, including the TCI / ETCI displays, paediatric models and mL/h conversions, for dosing decisions or dosing plans in actual patients. Real TCI pumps use algorithms validated by their manufacturers. - All calculations stay on your device; nothing is sent anywhere. There is no account, advertising or analytics. Author: Michiyoshi Sanuki, MD, PhD (anesthesiologist) Copyright (c) Michiyoshi Sanuki, 2026

Explore cardiac anatomy with a 3D heart and a synchronized model section. TEE is also known as TOE. This educational app is designed for medical professionals and learners. The free mode includes a beating heart and 28 selectable TEE view presets. An optional, user-initiated 7-day preview unlocks manual TEE probe controls. It does not convert to a paid purchase automatically. The heartbeat and view presets remain free afterward. One-time purchases unlock TEE, TTE & ICE, or all three modes together at a bundle price. TEE adds cycle pause and scrubbing, manual probe controls, transparent walls, valve-focused study, additional vascular views, and local save and resume. Its valve study connects mitral, aortic and tricuspid leaflets and commissures with the surrounding chambers and vessels. The TTE mode offers 12 anatomical view presets with probe tilt, rock and limited slide controls. ICE offers eight right-atrial view presets with catheter controls. These modes are illustrative prototypes for anatomy learning. A free index links to official guidelines on valves and cardiac function. The app can be switched among English, Japanese, Spanish, Simplified Chinese and Traditional Chinese. Models and saved study states work offline; purchases, restoration and external references require internet access. No subscription or app-specific account is required. The sections and cardiac motion are model-based illustrations, not acoustic ultrasound images. They are not clinically validated for diagnosis, measurements or wall-motion assessment. Use them alongside real images, textbooks and supervised training.