NbN3 vs SOBP 2025

It has become clear that the current pharmacological nomenclature of psychotropic medications does not reflect our contemporary knowledge, nor does it inform properly the clinician of neuroscience-based prescriptions. Very often we prescribe “antidepressants” for “anxiety” disorders or “second-generation antipsychotics” to depressed patients. This practice is confusing. • Five international organizations ECNP, ACNP, AsCNP, CINP & IUPHAR decided five years ago to establish a taskforce and gave it the mission to embed our current neuroscience advances in the nomenclature. • The scope is to include all the medications with CNS indications and to harness this new nomenclature to help clinicians when they are trying to figure out what would be the next rational “neuropsychopharmacological step”. • In this second edition 22 new medications were added so NbN includes now 130 medications. This proposed nomenclature aims to reflect the current pharmacological knowledge base and cannot necessarily represent the ultimate scientific truth. The taskforce that assembled could have taken the stand that our current knowledge base is not enough to define the primary target or the correct mechanisms of action. But as a taskforce, we feel that it’s better to present a cutting-edge scientific interpretation than to wait for the definitive conclusion. We need to treat our patients now, and we cannot postpone treatment until all the facts are known.   Therefore this nomenclature is based on: 1. The need to treat now. 2. Updated neuroscience insights. 3. The judgment of the members of the taskforce. Along these lines, we have come up with the following proposal: The Nomenclature: Pharmacology and Mode of Action – reflects the current knowledge and understanding about the targeted neurotransmitter/ molecule/system being modified and the mode/mechanism of action. We also added 4 additional dimensions 4 Additional Dimensions: Approved Indications – based on the recommendations of major regulatory bodies (e.g. FDA, EMA, etc.) Efficacy and Side Effects – Driven from positive single, large, RCT and/or “heavy solid weight” clinical data. Only prevalent or life-threatening side effects were included  Practical Note – Summarizes the clinical knowledge that has been "filtered" through the taskforce's "sieve" Neurobiology – This dimension is focused on the biology. It is divided into preclinical and clinical sections, with the emphasis on the latter For those who would like to know more abo derived from empirical data.ut the pharmacology, there is a direct link to the relevant site of IUPHAR – our collaborator in this endeavour.   As this is on-going process, we recognize that the product is imperfect. Based on your feedback (and taking into account the feedback of other colleges) new reports and findings, appropriate updates (e.g. later editions) will be undertaken.

On behalf of the Society of Biological Psychiatry (SOBP), it is our great pleasure to welcome you to the 2025 Annual Conference taking place in the vibrant city of Toronto, Canada where thought leaders, researchers and clinicians will converge at the Sheraton Toronto, from the 24-26 April 2025. This is a special event for the Society as we celebrate a legacy of 80 years of excellence in biological psychiatry, and we discuss plans to shape the future of the field. The theme of the conference is “Artificial Intelligence and Mental Health: A new landscape for research and practice” and the aim is to explore the intersection of artificial intelligence (AI) and mental health. The integration of AI in mental health research and practice is not just a promising frontier—it is swiftly evolving into a transformative force, offering tremendous potential while also presenting significant challenges. This year’s conference will feature a dynamic array of keynote presentations, panel discussions, workshops, and poster sessions, all designed to foster collaboration and spark innovative ideas that can lead to meaningful advancements in our field. We look forward to celebrating this milestone conference with you! We welcome your active participation, and we hope that the conference will be an enjoyable and productive experience.