T Calc vs ESC CVD Risk Calculation

The Free Testosterone and Bioavailable Testosterone Calculator application is designed to assist clinicians in accurately determining circulating bioactive testosterone levels. Simply plug in the appropriate lab values and push a button for fast, accurate results. How to use the Free & Bioavailable Testosterone Calculator The Free & Bioavailable Testosterone Calculator reduces the risk of errors that can occur when performing complicated calculations by hand. To use the app, input current lab values into the specified boxes for: - Albumin - SHBG - Testosterone Once lab values are in place, press the calculate button and let the Free & Bioavailable Calculator app do the math. Free & Bioavailable Testosterone Testosterone and dihydrotestosterone (DHT) circulate in plasma unbound (free approximately 2-3 percent), bound to specific plasma proteins (SHBG), and weakly bound to non-specific proteins such as albumin. The SHBG-bound fraction is biologically inactive because of the high binding affinity of SHBG for testosterone. Bioavailable testosterone measurement includes the free plus the weakly bound. Free testosterone measures the free fraction. Certain health conditions and medications, such as corticosteroids, can affect SHBG levels, impacting total serum testosterone concentration. Combining albumin, sex hormone-binding globulin (SHBG) and testosterone levels provides a more precise measurement of total serum testosterone concentration. Free Testosterone Reference Range Males (16 years and above): 9-30 ng/dL Females: 0.3–1.9 ng/dL Bioavailable Testosterone Reference Range Males: 20-29 years: 83-257 ng/dL 30-39 years: 72-235 ng/dL 40-49 years: 61-213 ng/dL 50-59 years: 50-190 ng/dL 60-69 years: 40-168 ng/dL >69 years: not established Females (non-oophorectomized) 20-50 years (on oral estrogen): 0.8-4.0 ng/dL 20-50 years (not on oral estrogen): 0.8-10 ng/dL >50 years: not established This website/app has been developed in part through an educational grant from Besins Healthcare (UK) Ltd. The company has no editorial control on its content. IMPORTANT LIMITATIONS: This calculator is an educational tool and should not be solely relied upon in making any clinical decision. No responsibility whatsoever is assumed for its correctness or suitability for any given purpose. Please consult your health care provider first for any health concerns. Additionally, the calculated free and bioavailable testosterone should not be relied upon in situations with potential massive interference by steroids binding to SHBG (e.g. in women during pregnancy, in men during treatment inducing high levels of DHT or Mesterolone.

The ESC CVD Risk Calculation App is designed for healthcare professionals. It provides calculators assessing individual cardiovascular risk. It includes calculators for primary and secondary prevention in various populations: 1. SCORE2 2. SCORE2-OP 3. SCORE2-Diabetes 4. ASCVD 5. SMART 6. SMART-REACH* 7. DIAL* 8. LIFE-CVD* * Available online on U-Prevent (Internet connection required) The ESC CVD Risk Calculation App is available in English. It provides guidance to the most adapted calculator for your patient, and provides an estimation of cardiovascular risk. Of note, patient data are not stored in the App. This application is only for informative use and is not intended to provide therapeutic support or diagnosis assistance. This Application is powered by the European Society of Cardiology (ESC), based upon the source codes of the U-Prevent webtool, a concept developed by University Medical Center Utrecht, redesigned and owned by ORTEC. The SCORE2, SCORE2-OP and SCORE2-Diabetes calculators were developed in collaboration with the ESC Cardiovascular Risk Collaboration unit. The Application has recently been updated in the framework of the EAPC IMPLEMENT Programme (2023) which was supported by Novo Nordisk in the form of an educational grant. The sponsor did not have any involvement or influence on the features nor on the scientific content within the Application.