Comparison

CDC Yellow Book vs Syphilis Tools

Price, ratings, monetisation and update history for both apps, side by side — with what reviewers say about each.

Head to head
About

CDC Yellow Book

Access the U.S. government's most current travel health guidelines, including vaccine recommendations and destination-specific advice. This app offers comprehensive information for staying healthy abroad, with features like search, notes, and favorites.

Highlights
  • Pre-travel vaccinations and preventative care
  • Destination-specific guidelines
  • Advice for travelers with specific health needs
  • Full text search
  • Custom notes and highlights
  • Reference maps, tables, and charts
Features
Read full description

**U.S. Government’s Most Current and Trusted Travel Health Guidelines** Preview, Buy, or Sign In using this app. FREE PREVIEW – Experience the Yellow Book to see the value of having trusted travel information when and where it's needed. ABOUT YELLOW BOOK The fully revised and updated 2020 CDC Yellow Book app delivers the U.S. government’s most current travel health guidelines, including pre-travel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. Authored by a team of the world’s most esteemed travel medicine experts, this app best codifies the U.S. Government’s latest travel guidelines to staying healthy anywhere in the world. Review dedicated topics on emerging infectious disease threats such as Zika, Ebola, and MERS, new cholera vaccine recommendations, updated guidance on the use of antibiotics to treat traveler’s diarrhea, special considerations for unique types of travel (i.e. wilderness expeditions, work-related travel, and studying abroad), and fully revised advice for specific destinations in international travel. FEATURES • Pre-travel vaccinations and preventative care • Destination specific guidelines with sections on Cuba and Burma • Advice for travelers with specific health needs (pregnant women, travelers with chronic illness, etc.) • Practical tips for last minute or resource limited travelers • Recommendations for air crews, humanitarian workers, missionaries, and others who provide care and support overseas • Easy to use reference maps, tables, and charts • Notes for making custom notes and highlights within entries • Full Text Search to find specific topics quickly • "Favorites" for bookmarking important topics EDITOR-IN-CHIEF: Gary W. Brunette Publisher: Oxford University Press Powered by: Unbound Medicine Unbound Privacy Policy: www.unboundmedicine.com/privacy Unbound Terms of Use: https://www.unboundmedicine.com/end_user_license_agreement

About

Syphilis Tools

This medical reference app provides healthcare professionals and trainees with up-to-date information on diagnosing, treating, and preventing syphilis. It includes tools for screening, serologic testing, staging, treatment, monitoring, and partner management, all based on CDC guidelines.

Highlights
  • CDC STI Treatment Guidelines
  • Offline accessibility
  • Geographic Risk Tool
  • Serologic Testing Interpretation
  • Nontreponemal Titer Tool
  • Treatment Regimen Summaries
  • Partner Management Guidance
Features
Read full description

The Syphilis Tools application is designed to give health care professionals, public health workers, and medical trainees relevant information and tools to help diagnose, treat, and prevent syphilis. Content is based on CDC STI Treatment Guidelines. It was developed for the National STD Curriculum (NSTDC) by the University of Washington Infectious Diseases Education & Assessment (IDEA) Program. The application addresses six primary areas: Screening: Information on screening recommendations for various patient populations. The Geographic Risk Tool allows users to quickly find county-level rates of primary and secondary syphilis in the United States and view syphilis screening recommendations. Serologic Testing: Users learn about the variety of tests and how to choose the appropriate test to order; interpret serologic tests results; and test cerebrospinal fluid. Reference materials for interpreting traditional and reverse syphilis screening algorithms are available. To help explain syphilis in a person with prior treatment, the Nontreponemal Titer Tool compares pretreatment and current treatment RPR or VDRL titers and interprets the results. Staging: Clinical criteria for understanding primary, secondary, latent, and tertiary syphilis and how to stage a patient. To help identify different manifestations, scientifically accurate medical illustrations are embedded in various sections. Treatment: Educational summaries of guideline-based medication regimens to treat stages and types of syphilis. How to treat individuals who are penicillin-allergic and/or pregnant are also addressed. Users can select multiple stages and types to explore the potential impacts on possible treatment regimens. Monitoring: Reference information on evaluating serologic response and titer changes. Users can select RPR or VDRL titers and review possible test interpretations via the Nontreponemal Titer Tool. Partner Management: Educational materials and guidance regarding the management of symptomatic and asymptomatic partners of persons diagnosed with syphilis. Features: • Content based directly on CDC STI Treatment Guidelines • Offline accessibility for use in environments without internet connection • Plain-text summaries and reference materials • Tools to help determine county-base geographic risk and compare changes in titers before and during treatment The application links to the National Network of STD Clinical Consultation Service which provides consultations for licensed healthcare professionals and STD program staff. ############### Medical Disclaimer ############### Syphilis Tools is an educational reference for health care providers. It is not a substitute for professional medical advice. Any person using this app should seek the advice of a physician or other qualified health care provider in addition to using this app before making any medical decisions.

Screenshots

CDC Yellow Book4 screens
Syphilis Tools4 screens

Verdict

The call

The clearest difference is review sentiment: Syphilis Tools at 100% against CDC Yellow Book's 20%. Syphilis Tools also leads on in-app purchases (none vs 2) and update cadence (every 11 days vs every 17 months). CDC Yellow Book's advantage is ratings volume (69 vs 2). On price, ads, device support and iOS requirement there is nothing between them.

Scored on Price · Rating · Positive reviews · Number of ratings · Update frequency · Ads · In-app purchases · Monetization · Best chart rank · Devices · Requires iOS

CostPrice · In-app purchases · Ads · Monetization

Both are free to download. CDC Yellow Book sells 1 one-off in-app purchase. Syphilis Tools asks for nothing beyond the download.

ReceptionRating · Positive reviews · Number of ratings

Syphilis Tools holds the better App Store score, 4.5 against 4.2. That said, the two scores are not equally well evidenced: CDC Yellow Book has 69 ratings behind it against 2, so its average is the more settled of the two. Written reviews point the same way: 20% of CDC Yellow Book's written reviews are positive against 100% of Syphilis Tools's.

UpkeepUpdate frequency

CDC Yellow Book ships an update every 17 months, Syphilis Tools every 11 days. The most recent releases landed on October 29, 2026 and October 28, 2026 respectively.

Scorecard6 real differences · 4 level
CDC Yellow Book versus Syphilis Tools: the parameters behind the verdict, then further details
ParameterCDC Yellow BookSyphilis Tools
PriceFreeFree
Rating4.2 (69 ratings)4.5 (2 ratings) — better
Positive reviews20.0% of reviews100.0% of reviews — better
Number of ratings69 — better2
Update frequencyEvery 17 monthsEvery 11 days — better
AdsNoNo
In-app purchasesYesNo — better
MonetizationFree with in-app purchasesFree — better
DevicesiPhone, iPad, iPodiPhone, iPad, iPod
Requires iOS15.015.0.0
Further details — not scored
Size10 MB57 MB
Age rating17+17+
DeveloperUnbound Medicine, Inc.University Of Washington

Customer experience

CDC Yellow Book

All ratings69 ratings
Positive81.2%
Neutral1.4%
Negative17.4%
Written reviews10 reviews
Positive20.0%
Neutral0.0%
Negative80.0%

Syphilis Tools

All ratings2 ratings
Positive100.0%
Neutral0.0%
Negative0.0%
Written reviews1 reviews
Positive100.0%
Neutral0.0%
Negative0.0%

In-app purchases

1 purchases

CDC Yellow Book

One-time1
  • CDC Yellow Book2 variants$29.99
None

Syphilis Tools

No in-app purchases

Questions

Is CDC Yellow Book free?
CDC Yellow Book is free to download, with in-app purchases available.
Is Syphilis Tools free?
Syphilis Tools is free to download, with no in-app purchases.
Which has better reviews, CDC Yellow Book or Syphilis Tools?
Syphilis Tools is rated higher. CDC Yellow Book averages 4.2 out of 5 from 69 ratings, while Syphilis Tools averages 4.5 from 2 ratings.
Do CDC Yellow Book or Syphilis Tools have ads?
Neither CDC Yellow Book nor Syphilis Tools shows ads.
Which is updated more often, CDC Yellow Book or Syphilis Tools?
CDC Yellow Book ships an update every 17 months, and Syphilis Tools every 11 days. Most recently, CDC Yellow Book was updated on October 29, 2026 and Syphilis Tools on October 28, 2026.

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