CARTOX vs Prezerve™

Cellular therapies can be associated with unique, acute toxicities which can be severe or even fatal if not identified early and treated appropriately. Cytokine Release Syndrome (CRS), the most commonly observed toxicity can range in severity from low-grade constitutional symptoms to high-grade syndrome associated with life-threatening multi-organ disfunction. Neurotoxicity, originally termed CRES (CAR-Related Encephalopathy Syndrome) and now updated to ICANS (Immune effector Cell-Associated Neurotoxicity Syndrome) is the second most-common adverse even and can occur concurrently with CRS. A multi-disciplinary working group was formed to address safety issues for patients receiving cellular therapy which led to the development of new grading methods and treatment algorithms that have been incorporated into the CARTOX mobile app. The CARTOX mobile app assists with grading toxicities, managing toxicities and assists with recommendations regarding appropriate antimicrobial prophylaxis for patients who have received immune effector cell therapy. Users are more easily able to determine if the patient is having cytokine release syndrome or neurotoxicity and to grade those toxicities. Intended audience: Clinicians (physicians, nurse practitioners, physician assistants, pharmacists, nurses) who treat/care for patients receiving immune effector cells.

The Prezerve™ Post-Transplant Symptom Tracker helps track, share, and better manage transplant-related symptoms during the crucial first 100 days post-transplant. TRACK AND SHARE SYMPTOMS • Track your symptoms on specific areas of your body and share photos and additional information with your care team in real-time. KEEP YOUR CARE TEAM UPDATED •You can keep your healthcare providers updated with your symptom report that shows symptom details, photos, and visualized data trends for symptom severity and frequency. LEARN MORE ABOUT YOUR POST-TRANSPLANT LIFE • Browse the library of articles to help you better identify, understand, and then communicate symptoms with your care team. The Prezerve™ Post-Transplant Symptom Tracker Mobile App is developed for patients, 18 years and older, who have recently received a bone-marrow transplant. Disclaimer! This mobile application is intended generally for symptom tracking and user education and not as a medical device. The information on this mobile application is not a substitute for a visit or a consultation with a healthcare professional. A healthcare professional is the single best source of medical advice regarding your health. Please consult a healthcare professional if you have any questions.