Best Disease Game

249+ iOS apps & games curated and reviewed

4.7 avg rating
17 free apps & games
Updated November 2026

If you already know Plague Inc., this is the deeper bench. 249+ disease game for iPhone, all reviewed and ranked by user rating, recency, and download trend as of November 2026.

Compare top Disease Game (November 2026)

#AppPriceRatingAdsIn-App PurchasesUpdated
1Plague Inc.Plague Inc.$0.994.8★ (168K)NoYesNov 2026
2Infection Bio WarInfection Bio WarFree4.6★ (20K)NoYesNov 2026
3Bio Inc. - Biomedical PlagueBio Inc. - Biomedical PlagueFree4.4★ (2.4K)NoYesNov 2026
4Bio inc. RedemptionBio inc. RedemptionFree4.7★ (2.2K)YesYesNov 2026
5Patient Zero: Virus gamePatient Zero: Virus gameFree4.6★ (5.1K)YesYesNov 2026
6VIRUS: OutbreakVIRUS: OutbreakFree—NoNoJul 2026
7Guy's Biobanking GameGuy's Biobanking GameFree—NoNoAug 2026
8Bad VirusBad VirusFree—NoNoMay 2026

Top Picks for Disease Game

Plague Inc.#1

Plague Inc. by Ndemic Creations

Can you Infect the World?
Editor's Choice
🎮 Games
4.8😊(168K ratings)
$0.99In-App Purchases
#1in Games
Plague Inc. screenshot 1
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Plague Inc. screenshot 6

A strategic simulation game where you evolve a deadly pathogen to infect the world and end humanity. Adapt your plague against global defenses and master different disease types to achieve victory. It's a high-stakes battle of strategy against the entire planet.

What We Love

  • 🚀 Addictive gameplay
  • 🤔 Challenging and thought-provoking
  • 👍 Realistic disease simulation
  • 💡 Unique scenarios and special disease types
  • 🎨 Immersive graphics and audio

Room to Improve

  • 💰 Expensive in-app purchases
  • 🕰️ Slow progression without paying
  • 🐛 Inconsistent game mechanics
  • 🤖 Unrealistic cure development
  • 🤔 Lack of multiplayer mode
Infection Bio War#2

Infection Bio War by Wildlife Studios, Inc

Spread the Plague!
Strong Contender
🎮 Games
4.6😊(20K ratings)
FreeIn-App Purchases
Infection Bio War screenshot 1
Infection Bio War screenshot 2
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Infection Bio War screenshot 4
Infection Bio War screenshot 5

A strategy game where you infect the global population with a custom disease. Evolve your pathogen with various transmission methods, symptoms, and resistances to achieve world domination.

What We Love

  • 👍 Decent for a free app
  • 👍 Fun and addictive
  • 👍 Pretty great with a winning strategy
  • 👍 Great game, one small issue
  • 👍 Entertaining but way easy
  • 👍 Addicting as heck
  • 👍 Amazing game, one small issue
  • 👍 Really good game
  • 👍 Awesome substitute, but some kinks
  • 👍 Really Fun
  • 👍 Great game, but one small issue
  • 👍 Addictive could be updated
  • 👍 Highly Recommend But One Problem
  • 👍 Great game
  • 👍 Amazing
  • 👍 Awesome game
  • 👍 AMAZING GAME

Room to Improve

  • 🐛 Certain African countries won't grow
  • 🐛 Worm gamemode has a bug
  • 🐛 Scrolling issues
  • 🐛 Unlocking features can be difficult
  • 🐛 Game becomes too easy
  • 🐛 Lack of new content and updates
  • 🐛 Unbalanced gameplay mechanics
  • 🐛 Uninspired and low-effort
  • 🐛 Rigged to make you lose
  • 🐛 Slow scrolling
  • 🐛 Game gets boring over time
  • 🐛 Terrible UI and user experience
  • 🐛 Plagiarism of Plague Inc.
Bio Inc. - Biomedical Plague#3

Bio Inc. - Biomedical Plague by DryGin Studios

Diseases and infection RTS
Worth Considering
🎮 Games
4.4😐(2.4K ratings)
FreeIn-App Purchases
Bio Inc. - Biomedical Plague screenshot 1
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Bio Inc. - Biomedical Plague screenshot 4
Bio Inc. - Biomedical Plague screenshot 5

Develop lethal illnesses to determine a victim's fate in this biomedical strategy simulator. Upgrade diseases, boost risk factors, and slow recovery before doctors find a cure. Offers hours of gameplay with realistic conditions and numerous stages.

What We Love

  • 🚀 Fun and addictive gameplay
  • 👍 Realistic and educational
  • 🤩 Excellent game concept
  • 💡 Ability to name the victim
  • 🎨 Great graphics and visuals

Room to Improve

  • 🐛 Frequent freezing and crashing issues
  • 💰 Expensive in-app purchases
  • 🔍 Unrealistic disease progression and recovery
  • 🙄 Too many ads
  • 🤔 Confusing or misleading mechanics

More Disease Game apps to explore

FAQ about Disease Game

What is the best disease game for iPhone?
Plague Inc. tops our disease game ranking as of November 2026, with a 4.8-star average from 168K App Store ratings, and it's priced at $0.99.
Yes — 17 of the top disease game we rank are free to download, including Infection Bio War and Bio Inc. - Biomedical Plague.
Plague Inc. has no ads and offers in-app purchases, according to its App Store listing as of November 2026.
We track 249+ disease game on the iOS App Store as of November 2026, ranked by rating, recency, and analysis of real user reviews.