BioCyc Pathway/Genome DBs vs COM

The BioCyc app provides mobile access to the BioCyc collection of 14,000+ pathway/genome databases, including MetaCyc, HumanCyc, YeastCyc, and many more. The BioCyc app includes the highly curated EcoCyc database for E. coli K-12, with content distilled from more than 36,000 publications. Use BioCyc Mobile in the laboratory, in the classroom, at a conference, or in the library. BioCyc Mobile can also connect to other Pathway/Genome Databases around the web that are running Pathway Tools software version 23.5 or newer. Features: • Browse, search, and save your favorite genes • Gene and protein sequence information, protein feature annotations • Regulation summary diagrams describe regulatory influences on a gene • Metabolic pathway diagrams • Gene Ontology terms • Links to other popular biological databases

COM simulates experiments with isolated mitochondria in an incubation chamber fitted with an oxygen electrode (oxygraph). Add mitochondria, substrates, ADP, inhibitors and uncouplers one after another and follow, in real time, O₂ consumption and the electrical potential of the inner membrane (Δψ). The challenge is to find out what each compound does: which ones stimulate oxygen consumption, which ones inhibit it, where each electron transport chain inhibitor acts and how uncouplers separate respiration from ATP synthesis. • 15 compounds: malate, pyruvate, α-ketoglutarate, succinate, TMPD + ascorbate, ADP + phosphate, rotenone, malonate, antimycin A, cyanide, carbon monoxide, oligomycin, 2,4-dinitrophenol and FCCP • Recording of dissolved O₂ and Δψ, with a numbered history of every addition • Several experiments side by side for comparison • Question guide for undergraduate classes and an answer table for teachers • Portuguese, English and Spanish Current version of the COM simulator, created in 1997 at the Educational Technology Laboratory (LTE), Institute of Biology, University of Campinas (Unicamp), and used in biochemistry courses ever since. Part of BIOQUÍMICA +30. Free, no ads, no sign-up and no data collection. Works offline.