Sage Math vs COM

A simple interface to the Sage computer algebra system. Through Sage it provides access to the GAP, GP, Maxima, Octave, R, and Singular computer algebra systems as well as Python and HTML. Knowledge of one of these systems is highly recommended. This is a lightweight alternative to the Sage online notebook. It is optimized for quick calculations. Network connectivity is required to perform calculations, but results are stored on the device for offline perusal and can be easily emailed to colleagues. Several buttons are added to the keyboard to simplify input. Sage is an open source computer algebra system combining many open source components and providing a consistent Python interface. There is an online notebook interface as well as a simplified web interface for quick calculations.

COM simulates experiments with isolated mitochondria in an incubation chamber fitted with an oxygen electrode (oxygraph). Add mitochondria, substrates, ADP, inhibitors and uncouplers one after another and follow, in real time, O₂ consumption and the electrical potential of the inner membrane (Δψ). The challenge is to find out what each compound does: which ones stimulate oxygen consumption, which ones inhibit it, where each electron transport chain inhibitor acts and how uncouplers separate respiration from ATP synthesis. • 15 compounds: malate, pyruvate, α-ketoglutarate, succinate, TMPD + ascorbate, ADP + phosphate, rotenone, malonate, antimycin A, cyanide, carbon monoxide, oligomycin, 2,4-dinitrophenol and FCCP • Recording of dissolved O₂ and Δψ, with a numbered history of every addition • Several experiments side by side for comparison • Question guide for undergraduate classes and an answer table for teachers • Portuguese, English and Spanish Current version of the COM simulator, created in 1997 at the Educational Technology Laboratory (LTE), Institute of Biology, University of Campinas (Unicamp), and used in biochemistry courses ever since. Part of BIOQUÍMICA +30. Free, no ads, no sign-up and no data collection. Works offline.