COM vs Molecules that changed the World

COM simulates experiments with isolated mitochondria in an incubation chamber fitted with an oxygen electrode (oxygraph). Add mitochondria, substrates, ADP, inhibitors and uncouplers one after another and follow, in real time, O₂ consumption and the electrical potential of the inner membrane (Δψ). The challenge is to find out what each compound does: which ones stimulate oxygen consumption, which ones inhibit it, where each electron transport chain inhibitor acts and how uncouplers separate respiration from ATP synthesis. • 15 compounds: malate, pyruvate, α-ketoglutarate, succinate, TMPD + ascorbate, ADP + phosphate, rotenone, malonate, antimycin A, cyanide, carbon monoxide, oligomycin, 2,4-dinitrophenol and FCCP • Recording of dissolved O₂ and Δψ, with a numbered history of every addition • Several experiments side by side for comparison • Question guide for undergraduate classes and an answer table for teachers • Portuguese, English and Spanish Current version of the COM simulator, created in 1997 at the Educational Technology Laboratory (LTE), Institute of Biology, University of Campinas (Unicamp), and used in biochemistry courses ever since. Part of BIOQUÍMICA +30. Free, no ads, no sign-up and no data collection. Works offline.

The "Molecules that changed the World" App is meant to convey the scientific facts and interesting stories of molecules that changed our culture, course of civilisation and in short, the world. Among the represented molecules are such basic compounds like water, carbon dioxide, ammonia, which not only influenced the way we think about resources, climate and food production but also affected the development of early life on Earth, and synthetic complex compounds such as nitroglycerin, polyethylene and aspirin. App is aiming at telling you more about the chemical background of such molecules and their influence onto the historical and cultural developments and the life as we know it. This app is a translation of the interactive 3D installation "Molecules that Changed the World" by Ljiljana Fruk and Bernd Lintermann, which was designed at ZKM/Institute for Visual Media to accompany the "Molecular Aesthetics" Symposium held at ZKM | Centre for Art and Media, Karlsruhe, Germany in 2011.