Immunity vs Pathogen Zero

YOU ARE THE LAST LINE OF DEFENSE. Play as a macrophage — the immune system's most powerful cell — and fight through 10 zones of the human body in this biology-based action roguelite. THE BODY IS UNDER ATTACK. From the Lymph Node to the Heart, real pathogens have invaded every organ. Bacteria. Parasites. Viruses. Kidney stones. Blood clots. Each zone brings new enemies grounded in actual cell biology — every creature, ability, and mechanic is based on how the immune system really works. BUILD YOUR IMMUNE RESPONSE. Every run is different. Collect 27+ adaptations and abilities as you progress — Cytokine Burst, Fever Mode, Phagocytosis, Neutrophil Swarm, Complement Cascade, and more. Stack upgrades. Build synergies. Adapt to every threat. 10 ZONES. 10 BOSSES. ▸ Lymph Node — face the Dormant Sentinel ▸ Lungs — battle the Pneumonia Mass ▸ Bloodstream — confront the Sepsis Herald ▸ Stomach — destroy H. Pylori Overlord ▸ Brain — survive the Neuroinflammation Prime ▸ Liver — fight the Cirrhosis Node ▸ Small Intestine — stop the Tapeworm Queen ▸ Large Intestine — dismantle the Bacterial Megacolony ▸ Kidneys — shatter the Nephrolithic Golem ▸ Heart — expel the Myocardial Invader THEN FACE THE FINAL BOSS. Cancer. The body's own cells gone wrong. A corrupted mirror of yourself. Three phases. Endless copies. No easy victory. ROGUELITE THAT RESPECTS YOUR TIME. ▸ Quick runs — each zone takes minutes ▸ Permanent upgrades carry between runs ▸ No energy systems. No paywalls. Play anytime. ▸ Every run feels different — 27+ items, abilities, and upgrades ▸ One more run feeling that turns five minutes into an hour LEARN WHILE YOU PLAY. Every enemy is a real pathogen. Every ability is a real immune response. Immunity is the only roguelite built on actual immunology — making it genuinely educational without ever feeling like homework. ▸ E. coli that groups and reforms ▸ Fibrin clots that regenerate HP ▸ Calcium oxalate crystals with mineral armor ▸ Platelet swarms that recruit more platelets ▸ A Cancer boss that proliferates when damaged Can the immune system hold?

The world is in your hands. And in your hands, it will die. Build a pathogen from a single cell and carry it to every corner of the planet. Start with a silent outbreak in one unlucky country… and don't stop until no one is left. But be careful: the moment the world notices you, the best labs on Earth race for the cure. It's you or humanity. Only one wins. A REAL WORLD A 1:1 world map with real data for every country: population, climate, healthcare, cities, airports, seaports and borders. Nigeria doesn't play like Iceland. A rich, cold country is a fortress; a hot, crowded megacity is a powder keg. EVOLVE WITHOUT LIMITS 13 pathogen types — Bacteria, Virus, Fungus, Prion, Bio-Weapon and lethal special plagues — each with its own playstyle. A full evolution tree: spread by air, water, blood and animals; symptoms that chain into devastating combos; and traits to resist cold, heat and drugs. REAL STRATEGY Symptoms make you deadly… but they expose you. Kill too fast and you'll speed up the cure. Hide too long and you'll kill no one. Every game is a knife-edge between stealth and aggression, with decision events that change everything. And yes — even on Normal you can lose if you play badly. MASTER IT A final score and letter grade (can you earn the S?), achievements, special scenarios and difficulties up to Mega Brutal. Easy to learn, brutal to master. No ads. No nonsense. Just you against 8 billion people. How fast can you wipe humanity off the map?