COM vs LIFE by THIX

COM simulates experiments with isolated mitochondria in an incubation chamber fitted with an oxygen electrode (oxygraph). Add mitochondria, substrates, ADP, inhibitors and uncouplers one after another and follow, in real time, O₂ consumption and the electrical potential of the inner membrane (Δψ). The challenge is to find out what each compound does: which ones stimulate oxygen consumption, which ones inhibit it, where each electron transport chain inhibitor acts and how uncouplers separate respiration from ATP synthesis. • 15 compounds: malate, pyruvate, α-ketoglutarate, succinate, TMPD + ascorbate, ADP + phosphate, rotenone, malonate, antimycin A, cyanide, carbon monoxide, oligomycin, 2,4-dinitrophenol and FCCP • Recording of dissolved O₂ and Δψ, with a numbered history of every addition • Several experiments side by side for comparison • Question guide for undergraduate classes and an answer table for teachers • Portuguese, English and Spanish Current version of the COM simulator, created in 1997 at the Educational Technology Laboratory (LTE), Institute of Biology, University of Campinas (Unicamp), and used in biochemistry courses ever since. Part of BIOQUÍMICA +30. Free, no ads, no sign-up and no data collection. Works offline.

Explore an interactive human body. Learn physiology and medicine in an innovative way. - Experiment with different medications, feed some food to the body, make it fall asleep, run some blood tests, monitor EKG of the heart... - Explore 200+ common medications, food and hormones. - Explore 100+ physiological and pathological conditions. - Observe each unique organ and learn about their functionalities. After all, they've accompanied you till now. - Experience emergency situations, provide artificial ventilation, start CPR, use the defibrillator... - Activate different scenarios: anxiety, allergy, inflammation... - Observe representations of biology receptors in each organs. - Tap any medical terms to learn more! * Medications in the app are only representative. The real mechanisms are much more complex. The effectiveness, interactions and onsite times are significantly simplified for the usage of the app and not always reflecting the real situation. * The intent of the content is to provide a constructive and educational platform for all users and is NOT intended as medical diagnosis. Any treatment of specific symptoms showcased in the app must be treated by a licensed physician. Read full terms of use at thix.co/life/terms