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Best Disease Outbreak Game

163+ iOS apps & games curated and reviewed

4.4 avg rating
17 free apps & games
Updated June 2026

Every iPhone needs a few good disease outbreak game apps. We benchmark 163+ of them on App Store rating, freshness, and pricing, then surface the standouts so you don't have to scroll the App Store yourself.

Top Picks for Disease Outbreak Game

Plague Inc.#1

Plague Inc. by Ndemic Creations LTD

Can you Infect the World?
Editor's Choice
🎮 Games
4.8😊(163K ratings)
$0.99In-App Purchases
#1in Games
Plague Inc. screenshot 1
Plague Inc. screenshot 2
Plague Inc. screenshot 3
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Plague Inc. screenshot 6

A strategic simulation game where you evolve a deadly pathogen to infect the world and end humanity. Adapt your plague against global defenses and master different disease types to achieve victory. It's a high-stakes battle of strategy against the entire planet.

What We Love

  • 🚀 Addictive gameplay
  • 🤔 Challenging and thought-provoking
  • 👍 Realistic disease simulation
  • 💡 Unique scenarios and special disease types

Room to Improve

  • 💰 Expensive in-app purchases
  • 🕰️ Slow progression without paying
  • 🐛 Inconsistent game mechanics
Patient Zero: Virus game#2

Patient Zero: Virus game by Brightika, Inc.

Apocalypse simulator
Strong Contender
🎮 Games
4.6😞(3.7K ratings)
FreeAdsIn-App Purchases
Patient Zero: Virus game screenshot 1
Patient Zero: Virus game screenshot 2
Patient Zero: Virus game screenshot 3
Patient Zero: Virus game screenshot 4
Patient Zero: Virus game screenshot 5
Patient Zero: Virus game screenshot 6

Simulate the creation and spread of a deadly plague in this realistic apocalypse simulator. Adapt your pathogen against global efforts to stop it and decide the fate of humanity. It's a strategic test of biology and survival.

What We Love

  • 👍 Great gameplay
  • 🚀 Smooth graphics

Room to Improve

  • 💸 Too many ads
  • 🔍 Lack of content
World Plague Pandemic: Evolved Zombie Invaders#3

World Plague Pandemic: Evolved Zombie Invaders by Oliver Saylor

Worth Considering
🎮 Games
2.4😐(70 ratings)
FreeIn-App Purchases
World Plague Pandemic: Evolved Zombie Invaders screenshot 1
World Plague Pandemic: Evolved Zombie Invaders screenshot 2
World Plague Pandemic: Evolved Zombie Invaders screenshot 3
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World Plague Pandemic: Evolved Zombie Invaders screenshot 5

Become the mastermind behind a global plague, evolving your virus to infect the world. Explore new game modes like Fighting the Cure and Survival, and utilize powerful bio-weapons to enhance your devastating spread. Upgrade your virus and conquer 9 level packs in this thrilling simulation.

What We Love

  • 🎮 Fun and addictive gameplay
  • 👍 Simple and easy to understand
  • 💡 Unique concept

Room to Improve

  • 🔍 Lack of depth and sophistication
  • 🔋 High ad frequency disrupting gameplay
  • 🐛 Occasional bugs and glitches

More Disease Outbreak Game apps to explore

4
Hospital Empire Tycoon - Idle
Hospital Empire Tycoon - Idle
Hospital Empire Tycoon - Idle
Health center management game
Free

Manage a bustling hospital, overseeing all departments to keep patients healthy and your business profitable. Upgrade facilities, adapt strategies, and manage staff to become a renowned hospital manager.

Manage hospital departmentsUpgrade facilities and unlock new areasDeal with patient emergencies
🎮 Games
(8.6K)
free with in-app purchases
5
Operation Outbreak
Operation Outbreak
Operation Outbreak
by THE BROAD INSTITUTE INC
Free

Engage in a virtual pathogen outbreak simulation using Bluetooth. Learn about disease spread and prevention through interactive gameplay, quizzes, and teamwork. Requires a code from an organizer to participate.

Bluetooth-enabled outbreak simulationLearn disease prevention strategiesInteractive quizzes on biology and public health
📚 Education
(138)
free
6
Virus Evolution: Destroy Earth
Virus Evolution: Destroy Earth
Virus Evolution: Destroy Earth
Spread the Bacteria Infection!
Free

Unleash a deadly pathogen and strategically spread a global pandemic. Your goal is to conquer humanity by increasing infection rates and decreasing survival rates. Become the ultimate threat and achieve world domination.

Spread the virusStart a pandemicConquer the world
🎮 Games
(848)
free with in-app purchases
7
Zombie Outbreak Simulator Pro
Zombie Outbreak Simulator Pro
Zombie Outbreak Simulator Pro
by Binary Space Pty Ltd
$4.99

Simulate and customize zombie outbreaks on real-world maps. Control outbreak parameters, observe infection spread, and even intervene with military support. Explore thousands of locations globally.

Real-world map simulationCustomizable outbreak parametersObserve infection spread
🎮 Games
(307)
paid
8
Zombie Outbreak Simulator
Zombie Outbreak Simulator
Zombie Outbreak Simulator
by Binary Space Pty Ltd
Free

Simulate and customize zombie outbreaks in real-world locations using Google Maps. Control outbreak parameters, observe chaos unfold, and even join the fight with military interventions. Explore thousands of player-created maps or offline options.

Real-world map simulation with Google Maps integrationCustomizable outbreak parameters (zombie speed, civilian numbers, etc.)Observe infection spread from satellite to street view
🎮 Games
(1.6K)
free with in-app purchases
9
Bio Inc. - Biomedical Plague
Bio Inc. - Biomedical Plague
Bio Inc. - Biomedical Plague
Diseases and infection RTS
Free

Develop lethal illnesses to determine a victim's fate in this biomedical strategy simulator. Upgrade diseases, boost risk factors, and slow recovery before doctors find a cure. Offers hours of gameplay with realistic conditions and numerous stages.

Biomedical strategy simulatorDevelop lethal illnessesUpgrade diseases and risk factors
🎮 Games
(2.4K)
free with in-app purchases
10
Pill Fortress
Pill Fortress
Pill Fortress
by Voodoo
Free

Defend your fortress against waves of viruses in this immune-themed base defense game. Strategically place and upgrade unique pill defenders to overcome evolving viral threats. Enjoy kid-friendly gameplay with vibrant 2D graphics.

Dynamic pill placementEvolving viral threatsUnlock new pill characters
🎮 Games
(3.3K)
free with in-app purchases
11
Last Asylum: Plague
Last Asylum: Plague
Last Asylum: Plague
by WISENESS GAME ONLINE INTERNATIONAL LTD
Free

Lead the last sanctuary as a plague doctor, managing resources, treating patients, and defending against a rat swarm. Strategically rebuild the town and reclaim abandoned ruins to guide survivors through a global pandemic.

Sanctuary managementPatient treatment and ward expansionHero recruitment and tower defense
🎮 Games
(26K)
free with in-app purchases
12
Virox: Global Outbreak
Virox: Global Outbreak
Virox: Global Outbreak
Survive zombies on sea shelter
Free

Lead a survivor settlement on a floating ice platform in a frozen, zombie-infested world. Rescue survivors, recruit heroes, build defenses, and forge alliances to endure the apocalypse.

Build floating ice fortressRescue and house survivorsRecruit legendary heroes
🎮 Games
(2.2K)
free with in-app purchases
13
3D Bio Hospital Infection Crisis - Zombie Outbreak
3D Bio Hospital Infection Crisis - Zombie Outbreak
3D Bio Hospital Infection Crisis - Zombie Outbreak
Snipe Un-dead Plague Humans
Free

Engage in a visually stunning bio-warfare FPS game against a zombie outbreak. Snipe infected humans and survive the undead assault in this thrilling chase game. Experience scary and amazing zombie shooting action.

Visually beautiful graphicsFPS style shootingZombie survival gameplay
🎮 Games
(19)
free with in-app purchases
14
Kill Shot Virus
Kill Shot Virus
Kill Shot Virus
Zombie Sniper Shooting Game
Free

Engage in over 100 first-person shooter missions to combat a zombie pandemic. Utilize a vast arsenal of weapons and gear to eliminate various zombie types and protect survivors. Join factions, compete globally, and survive intense event modes.

100+ FPS missionsLarge weapon arsenalApocalyptic gear customization
🎮 Games
(2.9K)
free with in-app purchases
15
After Inc.
After Inc.
After Inc.
What happens after Plague Inc?
$1.99

Rebuild civilization after a zombie apocalypse by building a settlement, exploring, and scavenging for resources. Make difficult societal decisions and defend against zombie threats in a persistent campaign.

Build and expand settlementsExplore a post-apocalyptic worldScavenge for resources
🎮 Games
(14K)
free with in-app purchases
16
3D Bio City Infection - Zombie Plague Crisis
3D Bio City Infection - Zombie Plague Crisis
3D Bio City Infection - Zombie Plague Crisis
Undead Sniper Shooter Game
Free

A first-person shooter where you battle hordes of zombies that have infected a city. Use a variety of weapons to clear the streets and survive the outbreak in this intense survival game.

Zombie survival gameplayFirst-person shooter actionVariety of weapons
🎮 Games
(9)
free with in-app purchases
17
The Walking Dead: Survivors
The Walking Dead: Survivors
The Walking Dead: Survivors
Game of Survival
Free

Lead a community of survivors in a post-apocalyptic world overrun by Walkers. Scavenge for supplies, build and defend your refuge, and recruit iconic characters. Make difficult choices between humanity and survival in this strategic game.

Explore unknown regionsFight Walkers and reclaim territoryRecruit and manage survivors
🎮 Games
(94K)
free with in-app purchases
18
Infection Bio War
Infection Bio War
Infection Bio War
Spread the Plague!
Free

A strategy game where you infect the global population with a custom disease. Evolve your pathogen with various transmission methods, symptoms, and resistances to achieve world domination.

Choose difficulty levelSelect starting countryEvolve disease transmission
🎮 Games
(20K)
free with in-app purchases
19
Infectonator
Infectonator
Infectonator
Worldwide arcade zombie panic
Free

Unleash a global zombie apocalypse by strategically infecting countries. Upgrade your undead army, unlock special abilities, and turn the world into your personal zombie playground. Enjoy vibrant pixel art and a humorous take on the zombie genre.

Worldwide zombie infectionZombie virus upgradesUnlock special undead
🎮 Games
(1.9K)
free with in-app purchases
20
Presidents War: Eat Dot Game - multiplayer cell eater in paradise hocus
Presidents War: Eat Dot Game - multiplayer cell eater in paradise hocus
Presidents War: Eat Dot Game - multiplayer cell eater in paradise hocus
by Linh Nguyen
Free

Control a hungry dot, consuming smaller dots to grow while avoiding larger ones. This version features meme-themed presidents on the dots for a unique and enjoyable experience. Compete globally for the highest score.

Eat smaller dots to growAvoid larger dotsMultiplayer gameplay
🎮 Games
(218)
free with in-app purchases