Best Disease Simulation Apps & Games

0+ iOS apps & games curated and reviewed

4.6 avg rating
18 free apps & games
Updated June 2026

Every iPhone needs a few good disease simulation apps and games. We benchmark 0+ of them on App Store rating, freshness, and pricing, then surface the standouts so you don't have to scroll the App Store yourself.

Compare top Disease Simulation Apps & Games (June 2026)

#AppPriceRatingAdsIn-App PurchasesUpdated
1Plague Inc.Plague Inc.$0.994.8★ (167K)NoYesSep 2026
2Eye Disease SimulatorEye Disease SimulatorFree was $2.99NoNoAug 2026
3Bio inc. RedemptionBio inc. RedemptionFree4.7★ (2.2K)YesYesSep 2026
4Bio Inc. - Biomedical PlagueBio Inc. - Biomedical PlagueFree4.4★ (2.4K)NoYesSep 2026
5Patient Zero: Virus gamePatient Zero: Virus gameFree4.6★ (4.4K)YesYesSep 2026
6Infection Bio WarInfection Bio WarFree4.6★ (20K)NoYesSep 2026
7Full Code Medical SimulationFull Code Medical SimulationFree4.8★ (6.3K)NoYesSep 2026
8Dream Hospital: Medical TycoonDream Hospital: Medical TycoonFree4.4★ (4K)YesYesSep 2026

Top Picks for Disease Simulation

Plague Inc.#1

Plague Inc. by Ndemic Creations

Can you Infect the World?
Editor's Choice
🎮 Games
4.8😊(167K ratings)
$0.99In-App Purchases
#1in Games
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A strategic simulation game where you evolve a deadly pathogen to infect the world and end humanity. Adapt your plague against global defenses and master different disease types to achieve victory. It's a high-stakes battle of strategy against the entire planet.

What We Love

  • 🚀 Addictive gameplay
  • 🤔 Challenging and thought-provoking
  • 👍 Realistic disease simulation
  • 💡 Unique scenarios and special disease types
  • 🎨 Immersive graphics and audio

Room to Improve

  • 💰 Expensive in-app purchases
  • 🕰️ Slow progression without paying
  • 🐛 Inconsistent game mechanics
  • 🤖 Unrealistic cure development
  • 🤔 Lack of multiplayer mode
Bio inc. Redemption#3

Bio inc. Redemption by DryGin Studios

Medical & Doctor Simulation
Worth Considering
🎮 Games
4.7😐(2.2K ratings)
FreeAdsIn-App Purchases
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Engage in a complex biomedical simulation where you can either create deadly illnesses to infect victims or lead a medical team to find cures. Explore two distinct campaigns, develop strategies, and compete in world tournaments. The game offers realistic medical scenarios with a focus on strategic decision-making.

What We Love

  • 👍 Fun and interesting gameplay
  • 🚀 Realistic and challenging
  • 💡 Ability to choose between saving or killing the patient
  • 👍 Teaches about diseases and medicine

Room to Improve

  • 🐛 Frequent crashes and freezes
  • 🐛 Issues with energy/coin system and power-ups
  • 🐛 Bugs with completing levels and earning rewards
  • 🐛 Loading problems and unresponsive app

More Disease Simulation apps to explore

FAQ about Disease Simulation

What are the best disease simulation apps & games for iPhone?
Plague Inc. tops our disease simulation apps & games ranking as of June 2026, with a 4.8-star average from 167K App Store ratings, and it's priced at $0.99.
Yes — 18 of the top disease simulation apps & games we rank are free to download, including Eye Disease Simulator and Bio inc. Redemption.
Plague Inc. has no ads and offers in-app purchases, according to its App Store listing as of June 2026.
Plague Inc. is a unique strategy simulation game where your goal is to evolve a deadly pathogen and infect the world, bringing about the end of human history. You must adapt your plague against everything humanity does to defend itself, making it a high-stakes battle of strategy.
The game features stunning retina graphics, a hyper-realistic world with advanced AI, and a comprehensive tutorial system. You can master 12 different disease types with unique strategies, infect over 50 countries, and evolve hundreds of traits. It also includes expansion updates like the Neurax Worm and Necroa Virus.